Could lidocaine replace opioids in emergency surgery recovery?
NCT ID NCT07262242
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two anesthesia methods for emergency abdominal surgery: one using the opioid fentanyl, and another using lidocaine to reduce opioid use. The goal is to see if the opioid-sparing approach leads to better recovery quality, fewer side effects like nausea and breathing problems, and less pain. The trial plans to enroll 120 adults aged 21-65 who need emergency laparotomy.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- lidocaine
- What this could lead to
- If it works, this could offer a safer pain control method for emergency abdominal surgery, reducing side effects and speeding recovery.
- What could go wrong
- This is a small, early-stage trial (120 people) that hasn't started yet. Lidocaine may not work as well as opioids for severe pain, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2025
An estimate. Start dates often move.
- Expected to finish
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Apr 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients (21-65 years), ASA I-III undergoing emergency laparotomy with midline incision Exclusion Criteria: * Severe cardiac morbidities (impaired contractility with ejection fraction \< 45%, heart block, arrhythmias, tight valvular lesions) * Patients on vasopressor infusion, patients with high shock index (heart rate / systolic blood pressure \>1) * Body mass index \<18 or \> 35 Kg/m2, * Pregnant or lactating women, * Allergy of any of the study drugs * Severe liver cell failure and renal impairment by history and/or abnormal liver and kidney function tests.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Kasr Alainy Hospital
Cairo, 11562, Egypt
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