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Breathing breakthrough: safer ventilation during emergency surgery could save lives

NCT ID NCT03987789

Disease control Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two different ways of using a breathing machine during emergency abdominal surgery. One method used higher air pressure to keep the lungs open, while the other used lower pressure to avoid overstretching the lungs. The goal was to see which approach led to fewer lung complications and deaths after surgery. The study included 707 adults who needed emergency abdominal surgery lasting at least two hours.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

707 people

The number who actually took part.

Started

Feb 2021

Finished

Oct 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult (≥18 years) * Patients requiring emergency (defined by the need to proceed to surgery within a few hours after diagnosis) * Laparoscopic or non-laparoscopic abdominal surgery under general anesthesia and with an expected duration of at least two hours Exclusion Criteria: * Patients already receiving mechanical ventilation for more than 12 hours before enrollment * Intracranial hypertension * Chronic respiratory disease requiring oxygen therapy or mechanical ventilation at home * Undrained pneumothorax or subcutaneous emphysema * Patients for which death is deemed imminent and inevitable or patients with an underlying disease process with a life expectancy of less than 3 month * Body mass index (BMI) \>40 kg/m2 * Pregnant or breastfeeding women * Patients already enrolled in the IMPROVE-2 trial * Participation in a confounding trial with mortality or PRF as the main endpoint * Patient's or relative's refusal to participate * Guardianship or trusteeship patient * No affiliation to the Social Security system

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Emergency abdominal surgery General anesthesia Mechanical ventilation Postoperative morbidity

Contacts and locations

Locations

  • Assistance Publique-Hôpitaux de Marseille

    Marseille, France

  • Assistance Publique-Hôpitaux de Paris

    Paris, France

  • Hospital

    Annecy, France

  • Hospital

    Chalon-sur-Saône, France

  • Hospital

    Périgueux, France

  • Hospital

    Suresnes, France

  • Hospital

    Valenciennes, France

  • Institut Paoli Calmette

    Marseille, France

  • University Hospital

    Bordeaux, France

  • University Hospital

    Nantes, France

  • University hospital

    Angers, France

  • University hospital

    Besançon, France

  • University hospital

    Clermont-Ferrand, France

  • University hospital

    Dijon, France

  • University hospital

    Grenoble, France

  • University hospital

    Le Mans, France

  • University hospital

    Lille, France

  • University hospital

    Lyon, France

  • University hospital

    Marseile, France

  • University hospital

    Marseille, France

  • University hospital

    Montpellier, France

  • University hospital

    Nice, France

  • University hospital

    Nîmes, France

  • University hospital

    Pointe à Pitre, 97159, France

  • University hospital

    Rennes, France

  • University hospital

    Saint-Etienne, France

  • University hospital

    Strasbourg, France

  • University hospital

    Toulouse, France

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