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Nerve zap could ease chronic headache from painkiller overuse

NCT ID NCT07360782

Symptom relief Sponsor: Ankara City Hospital Bilkent Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests a procedure called occipital nerve pulsed radiofrequency for people with medication overuse headache. The treatment uses a short electrical pulse on nerves at the back of the head to try to reduce headache days. 90 adults will be randomly assigned to get the procedure plus standard care, or standard care alone, and tracked for 6 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
greater occipital nerve pulsed radiofrequency (GONPRF) procedure
What this could lead to
If it works, this could offer a new way to reduce headache days for people with medication overuse headache, possibly helping them rely less on painkillers.
What could go wrong
This is a small, early-stage trial with only 90 people. The procedure may not work better than standard care, and there are risks like pain or nerve damage from the injection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Age 18-65 years * Diagnosed with Medication Overuse Headache (MOH) according to ICHD-3 criteria * No laboratory evidence of bleeding or clotting disorders * No active infection * Not pregnant and no suspicion of pregnancy * No history of craniocervical surgery that may alter anatomical structures at the intervention site * Able to understand the study procedures, provide written informed consent, and comply with treatment Exclusion Criteria * Changes in preventive treatment for migraine and/or tension-type headache within the last 3 months * Severe systemic disease (e.g., uncontrolled diabetes, serious cardiovascular disease, malignancy) * Psychiatric disorders (including current antidepressant use or psychiatric follow-up) * History of alcohol or substance abuse * Pregnancy, breastfeeding, or plans for pregnancy in the next 12 months * Concurrent use of other prophylactic headache treatments

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Conditions

The condition(s) this trial relates to.

Headache Disorders, Secondary

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Medication overuse headache

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ankara Bilkent City Hospital

    RECRUITING

    Ankara, 06800, Turkey (Türkiye)

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