Nerve zap could ease chronic headache from painkiller overuse

NCT ID NCT07360782

Recruiting now Symptom relief Sponsor: Ankara City Hospital Bilkent Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests a procedure called occipital nerve pulsed radiofrequency for people with medication overuse headache. The treatment uses a short electrical pulse on nerves at the back of the head to try to reduce headache days. 90 adults will be randomly assigned to get the procedure plus standard care, or standard care alone, and tracked for 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: greater occipital nerve pulsed radiofrequency (GONPRF) procedure
What this could lead to: If it works, this could offer a new way to reduce headache days for people with medication overuse headache, possibly helping them rely less on painkillers.
What could go wrong: This is a small, early-stage trial with only 90 people. The procedure may not work better than standard care, and there are risks like pain or nerve damage from the injection.

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Conditions

The condition(s) this trial relates to.

Headache Disorders, Secondary

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MEDICATION OVERUSE HEADACHE

Contacts and locations

Locations

Ankara Bilkent City Hospital
RECRUITING

Ankara, 06800, Turkey (Türkiye)

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