Could zapping the brain help treat anorexia? new trial investigates
NCT ID NCT05788042
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether two types of non-invasive brain stimulation—rTMS and tDCS—can improve symptoms of anorexia nervosa. Seventy participants in an inpatient setting will receive either active or sham (placebo) stimulation over 8 weeks. Researchers will measure changes in eating disorder behaviors, mood, and weight, and see if benefits last up to 20 weeks. The goal is to find a safe, acceptable treatment that could reduce hospital stays and improve daily functioning.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS)
- What this could lead to
- If it works, this could point toward a non-invasive, at-home treatment option to reduce eating disorder symptoms and hospital stays for people with anorexia nervosa.
- What could go wrong
- This is an early, small trial (70 people) comparing two brain stimulation methods against sham. It may not show clear benefits, and results may not apply to all patients with anorexia.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 70 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2023
- Expected to finish
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Apr 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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16 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged ≥16 years, * A current Diagnostic and Statistical Manual of Mental Disorders (5th edition DSM-5) diagnosis of anorexia nervosa * Willing and able to participate and comply with study requirements * Worked or studied in a context requiring some proficiency in spoken English (to ensure validity of neuropsychological testing) * Under ongoing care by his/her own treating psychiatrist (to ensure patient safety during the study) Exclusion Criteria: * Inability to provide informed consent * Contraindications to tDCS/rTMS * Failed to respond to an adequate course or rTMS (4 weeks) within the current illness course * Had ECT in the last 3 months * MoCA score of \<26 * Significant risk of significant self harm or suicide as assessed by study psychiatrist(s) * Currently enrolled in another interventional clinical trial or using an investigational device/product
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Northside Clinic
RECRUITINGSydney, New South Wales, 2031, Australia
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Other studies related to the condition(s) this trial covers.
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- Can a parent support group help teens with both autism and anorexia?
- Lab-Grown brain cells could unlock Anorexia's secrets
- Can science unlock the secrets of the naturally lean?