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Can rehab wake the brain? new study seeks answers

NCT ID NCT07385508

Knowledge-focused Sponsor: IRCCS Centro Neurolesi Bonino Pulejo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at 140 people with disorders of consciousness, like a vegetative state or minimally conscious state, caused by brain injury. Researchers will test different rehabilitation methods, including sensory stimulation, brain stimulation, and eye-tracking communication devices. The goal is to see which treatments help improve consciousness and daily function, and to find clues about who benefits most.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 140 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jan 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients with a diagnosis of VS/UWS or MCS, admitted to the Neurorehabilitation/GCA Unit of the Piemonte/Casazza Hospital (IRCCS Centro Neurolesi Bonino-Pulejo) and treated according to clinical practice with one or more of the following non-invasive approaches, will be included: multimodal sensory stimulation (SS), tDCS, TMS, AAC devices with eye-tracking, standard physiotherapy/speech therapy.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of VS/MCS following ABI, according to clinical and neuroradiological findings. * Age between 18 and 90 years. * Adequate pulmonary gas exchange function (PaO₂ / FiO₂ ratio ≥ 250). * Stable haemodynamic profile (absence of significant arterial variations in mean arterial pressure and/or heart rate). Exclusion Criteria: * Diagnosis of DOC due to non-structural aetiopathogenesis. * Having previously undergone multiple rehabilitation cycles * Being affected by deafness and/or blindness * Having unstable intracranial pressure values * Having cerebral perfusion values below 60 mmHg * Having other concomitant medical conditions that could interfere with the rehabilitation

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Conditions

The condition(s) this trial relates to.

Consciousness Disorders Persistent Vegetative State

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Disorder of consciousness

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • IRCCS Centro Neurolesi Bonino-Pulejo

    RECRUITING

    Messina, Sicily, 98066, Italy

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