Botulinum injection trial for arm spasticity halted early
NCT ID NCT04815967
First seen Jun 07, 2026 · Last updated Jun 22, 2026 · Updated 5 times
Summary
This study tested whether injections of MYOBLOC (botulinum toxin type B) can safely reduce muscle tightness in the arm and hand of adults with spasticity caused by stroke, brain injury, multiple sclerosis, or other conditions. The trial planned to enroll about 300 participants but was terminated early after only 32 people joined. Researchers measured changes in muscle tone and overall function four weeks after a single injection.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Centrum Medyczne Linden
Krakow, 31-721, Poland
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Coastal Neurology
Port Royal, South Carolina, 29935, United States
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Idaho Physical Medicine and Rehabilitation
Boise, Idaho, 83706, United States
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National Institute of Medical Rehabilitation
Budapest, H-1121, Hungary
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Niepubliczny Zaklad Opieki Zdrowotnej (NZOZ) Neuromed
Lubin, 20-604, Poland
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Rancho Research Institute
Downey, California, 90242, United States
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Specjalistyczna Praktyka Lekarska
Katowice, 40-097, Poland
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Specjalistyczne Gabinety Sp. zo.o
Krakow, 30-539, Poland
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MYOBLOC (rimabotulinumtoxinB, botulinum toxin type B)
What this could lead to
If it works, this could offer a treatment option to reduce muscle stiffness and improve arm function in people with spasticity from stroke, brain injury, or multiple sclerosis.
What could go wrong
The trial was terminated early with only 32 participants, so results are limited. Botulinum toxin injections can cause muscle weakness, pain, or allergic reactions, and effects are temporary.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.