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Tooth enamel defect study probes hidden inflammation in kids

NCT ID NCT07008599

Knowledge-focused Sponsor: Marmara University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at children aged 8 to 13 with a common enamel defect called Molar-Incisor Hypomineralization (MIH). Researchers measured inflammatory markers in the pulp (nerve) of affected teeth and compared them to healthy teeth. The goal was to better understand how MIH affects the inner tooth and potentially improve future diagnosis and treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help dentists better diagnose and treat MIH-related tooth problems by understanding the inflammation involved.
What could go wrong
This is a small, completed observational study, not a treatment trial. Results may not lead to immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

83 people

The number who actually took part.

Started

Mar 2024

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

8 to 13 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children aged between 8 and 13 years who were cooperative (able to comply with instructions) * Without any systemic diseases, syndromes, anomalies, or known allergies * First permanent molars requiring pulp therapy were included in the study. Exclusion Criteria: * Patients who had used antibiotics within the last month * Teeth deemed unrestorable * Teeth showing lamina dura loss or pathological root resorption on radiographic examination * Teeth that had previously undergone endodontic treatment * Teeth with internal or external root resorption * Teeth presenting with pus, necrosis, or exudate at the exposure site during treatment * Teeth in which no pulp exposure occurred during the procedure

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Conditions

The condition(s) this trial relates to.

dental pulp disorder dentin sensitivity inflammatory disease Molar Hypomineralization

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Inflamation Molar-incisor hypomineralization (MIH) Pulp disease, dental

Contacts and locations

Locations

  • Marmara Üniversitesi Recep Tayyip Erdoğan Külliyesi Sağlık Yerleşkesi, Diş Hekimliği Fakültesi, Başıbüyük Yolu 9/3 34854 Başıbüyük / Maltepe / İSTANBUL

    Istanbul, Beypazarı, 34854, Turkey (Türkiye)

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