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Silver liquid and light aim to numb the pain of brittle teeth

NCT ID NCT07826130

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Molar-incisor hypomineralization (MIH) makes first permanent molars weak, sensitive, and painful to treat. This trial tests two desensitizing approaches, nano silver fluoride and photobiomodulation therapy, in children aged 7 to 12 with MIH-affected molars. Researchers compare these against pre-appointment pain medicine, measuring sensitivity and pain during cavity preparation and restoration. All treated teeth receive glass ionomer fillings, which are checked at 3, 6, and 12 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nano silver fluoride, a silver-based liquid applied to teeth, and photobiomodulation therapy, a low-level light treatment
What this could lead to
If it works, this could give dentists a simple way to calm sensitive teeth before treating children with molar-incisor hypomineralization, making visits less painful.
What could go wrong
The trial is small, with 45 children, and compares two approaches against pain medicine. Neither may ease pain better than the standard option, and results in children may not apply to adults.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2027

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

7 to 12 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children aged 7-12 years diagnosed with molar-incisor hypomineralization (MIH) in first permanent molars according to the European Academy of Paediatric Dentistry (EAPD) criteria. * MIH-affected teeth exhibiting demarcated opacity, post-eruptive structural loss of enamel, and hypersensitivity (Treatment Need Index = 4). * Children who are able to cooperate during treatment and attend scheduled follow-up visits. * Children whose parents or legal guardians provide informed consent for participation in the study. Exclusion Criteria: * Hypomineralized molars caused by other conditions, including syndromes, fluorosis, enamel hypoplasia, amelogenesis imperfecta, or dental caries. * Teeth with defective restorations or pulpal symptoms. * History of desensitizing treatment within the previous 6 months. * Use of anti-inflammatory drugs or analgesics at the time of recruitment. * Children who are physically or mentally disabled or who have a medical condition that may complicate treatment. * Reported allergy to silver or any material included in the study.

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Conditions

The condition(s) this trial relates to.

Molar Hypomineralization

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Molar-incisor hypomineralization (MIH)

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  2. A doctor treating you

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