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Scientists probe the genetic origins of menstruation by comparing human and primate uterine tissue

NCT ID NCT05412771

Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study aims to understand the evolutionary and cellular basis of menstruation, a trait unique to primates. Researchers collect uterine tissue samples from women undergoing surgery for benign conditions and compare them with samples from other primates. By analyzing gene activity and regulatory elements, they hope to identify the genetic changes that led to menstruation and better characterize the uterine lining for future medical insights.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could reveal the evolutionary origins of menstruation and improve understanding of uterine health, potentially informing treatments for menstrual disorders.
What could go wrong
This is a small, observational study focused on basic biology, not a treatment trial. Findings may not directly translate to medical applications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2022

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Be between 18 and 50 years old. * Have mensturation at the time of their participation * Have given their written consent * Have an indication for surgery of hysteroscopy for removal of a polyp and/or fibroid and/or endometrial, endometrialctomy for presumed benign pathology and/or management of a uterine malformation, scheduled between days 21 and 25 of their menstrual cycle * Covered by social security Exclusion Criteria: * Using an intrauterine device contraceptive method during the study or within the previous three months * To be Pregnant at the time of collection * Have been pregnant in the three months prior to collection * Have had amenorrhoea in the three months prior to collection * Have received hormonal treatment within the three months prior to collection * Have participated in a clinical study within 3 months prior to collection * Have a personal history of breast, ovarian, body or cervical cancer * Have a diagnosis of endometriosis * Have a diagnosis of adenomyosis * Have a diagnosis of Lynch syndrome * Undergoing hysteroscopy for a condition other than those listed in the inclusion criteria * Women who have not given written consent * Women who are breastfeeding * Women with a body mass index (BMI) of less than 18.5 or more than 30

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Menstruation

Contacts and locations

Locations

  • Pitié salpétrière

    Paris, France

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