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New imaging technique could Fine-Tune ventilator settings for lung patients

NCT ID NCT07379242

Knowledge-focused Sponsor: Peking Union Medical College Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study will enroll 50 mechanically ventilated patients with acute respiratory failure to compare two methods of assessing lung recruitment: the recruitment-to-inflation ratio (R/I ratio) and 2D/3D electrical impedance tomography (EIT). Participants will undergo a standardized PEEP titration procedure while being monitored with both techniques. The goal is to see if these methods give consistent results, which could help doctors better tailor ventilator settings in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could improve how doctors set ventilator settings for patients with acute respiratory failure, potentially leading to better lung protection.
What could go wrong
This is a small observational study (50 participants) that does not test a treatment. It only compares measurement methods, so direct patient benefit is not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with acute respiratory failure who are intubated, under sedation and analgesia with controlled ventilation and no spontaneous breathing will be recruited from the Department of Critical Care Medicine, Peking Union Medical College Hospital. Additional inclusion criteria include an oxygenation index of less than 300 mmHg, clinical judgment indicating the need for PEEP titration, and no contraindications to PEEP titration or EIT examination.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Mechanically ventilated patients under sedation and analgesia with no spontaneous breathing. * Oxygenation index \< 300 mmHg. * Patients who are clinically judged by the attending doctor to require the PEEP titration. Exclusion Criteria: * Aged under 18 years. * Pregnancy. * Contraindications for EIT examination (e.g. automatic implantable cardioverter defibrillator, implantable pumps, chest wounds limiting electrode belt placement, severe thoracic deformity, and others). * No informed consent obtained. * Hemodynamic instability with intolerance to high PEEP levels determined by the attending doctor. * High-risk populations with pneumothorax, mediastinal emphysema, and other such conditions determined by the attending doctor.

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Conditions

The condition(s) this trial relates to.

acute respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory failure (ARF)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences

    RECRUITING

    Beijing, Beijing Municipality, 100730, China

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