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Breathing in a new way to see lungs: MRI with tracer gases

NCT ID NCT04726618

Knowledge-focused Sponsor: The Hospital for Sick Children Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested two special gases (hyperpolarized xenon and perfluoropropane) that people inhale to make their lungs show up better on an MRI. The goal was to develop better imaging methods and hardware to get clearer pictures of lung function. The study involved 24 healthy volunteers aged 6 to 75 and focused on improving image quality and comparing the two gases.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Hyperpolarized 129-xenon gas and perfluoropropane gas
What this could lead to
If successful, this could lead to better, safer ways to image lung function without radiation, helping diagnose lung diseases more accurately.
What could go wrong
This was a small, early-stage study in healthy volunteers that was terminated, so results are limited. The techniques may not work as well in people with lung disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

24 people

The number who actually took part.

Started

Mar 2022

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

50 male and females aged 6-75 with no history of respiratory disease will be used for this study.

Ages

6 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Consent provided * Aged 6-75 years old * In good general health as evidenced by medical history * Meets MRI screening criteria Exclusion Criteria: * Has diagnosis of pulmonary disease * FEV1 \<70% * Requires supplemental oxygen * Has had a respiratory infection within the past 2 weeks * Pregnant or lactating\*

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy volunteers

Contacts and locations

Locations

  • Hospital for Sick Children

    Toronto, Ontario, M5G 0A4, Canada

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Other studies related to the condition(s) this trial covers.