New Low-Cost radiation therapy could make liver cancer treatment accessible for all

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age greater than or equal to 18 years (male or female) 2. Histologically or radiologically confirmed diagnosis of HCC deemed inoperable 3. Barcelona Clinic Liver Cancer stage B with ECOG performance status between 0 and 2 4. At least one measurable lesion with longest diameter greater than or equal to 5 cm on cross sectional imaging 5. Portal vein thrombosis may be present or absent 6. Laboratory criteria: 1. Serum creatinine less than or equal to 1.5 mg per dL 2. Total bilirubin less than or equal to 2.0 mg per dL 3. AST or ALT less than or equal to 5 times upper limit of normal 4. Leukocyte count greater than or equal to 1500 per microliter 5. Platelet count greater than or equal to 50000 per microliter 6. Prothrombin time less than or equal to 1.3 times control or INR less than or equal to 1.5 7. Karnofsky performance status greater than 70 8. Ability and willingness to provide written informed consent for participation in the IEC approved protocol Exclusion Criteria: 1. Women of childbearing potential who are unwilling or unable to use effective contraception or who are pregnant or lactating 2. Child Pugh class C liver function 3. Presence of extrahepatic metastases 4. Severe chronic pulmonary disease with hypoxemia or NYHA class three or four heart failure 5. Myocardial infarction within the past six months 6. Unstable arrhythmia or symptomatic cardiac disease 7. Any other serious uncontrolled illness that in the investigator's opinion would compromise study participation 8. History of other malignancy except adequately treated basal cell carcinoma or cervical carcinoma in situ within the last five years 9. Major surgery within four weeks prior to enrolment 10. Active uncontrolled bacterial infection requiring systemic therapy 11. Liver rupture, tumor penetration of the liver capsule, tumor invasion of the biliary system, or biliary obstruction 12. Known allergy or hypersensitivity to any component of the investigational or comparator microspheres 13. Prior treatment with Selective Internal Radiation Therapy (SIRT) 14. Estimated overall survival less than one month