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New drug combo may speed up miscarriage management

NCT ID NCT07636317

Disease control Sponsor: Sohag University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding letrozole to misoprostol helps end a nonviable pregnancy in the first trimester more effectively than misoprostol alone. 400 women with missed miscarriage took part. Researchers measured bleeding, time to complete abortion, and side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Letrozole and Misoprostol
What this could lead to
If adding letrozole works better, it could offer a more effective and faster medication option for managing missed miscarriage.
What could go wrong
This is a completed trial, but results may not apply to all women. Side effects like nausea, fever, and shivers are possible with misoprostol.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

400 people

The number who actually took part.

Started

Jun 2025

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age from 18 to 45 years. * Women with nonviable pregnancies undergoing 1st-trimester abortion. Exclusion Criteria: * Medical diseases like renal or liver disease. * Severe bleeding and shocked patients. * Inevitable abortion. * Hypersensitivity to any of the drugs.

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Conditions

The condition(s) this trial relates to.

Abortion, Missed pregnancy disorder with abortive outcome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Induction Letrozole Misoprostol Missed abortion

Contacts and locations

Locations

  • Sohag University

    Sohag, 82511, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.