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Pill or insert? study tests best way to use misoprostol for early pregnancy loss

NCT ID NCT07526064

Disease control Sponsor: Hamna Khaliq Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two ways of giving misoprostol—by mouth or vaginally—to women who have a missed abortion in the first trimester. The goal is to see which route works better and causes fewer side effects. One hundred women will take part, and researchers will measure how quickly the pregnancy tissue is expelled and whether any remains in the uterus.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
misoprostol
What this could lead to
If successful, this could help doctors choose the best route for misoprostol to manage missed abortion with fewer side effects.
What could go wrong
This is a small, early-phase trial (Phase 1) with only 100 participants. Results may not apply to all women, and the optimal route may still be unclear.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Parity \<5 * Presenting with missed abortion (defined as spontaneous loss of pregnancy, presence of lower abdomen cramps, ultrasound scan shows no fetal cardiac activity during 8-16 weeks of pregnancy) Exclusion Criteria: * Pregnancy with any degree of cervical dilatation * Signs or symptoms of infection, * Twin gestation sac, molar pregnancy (on ultrasound), * Excessive uterine bleeding, * Blood pressure ≥160/90 mmHg, * Maternal history of asthma or cardiac or cerebral disease

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Conditions

The condition(s) this trial relates to.

Abortion, Missed pregnancy disorder with abortive outcome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Missed abortion

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • PNS Hafeez

    Islamabad, 44000, Pakistan

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