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A new topical treatment may spare teeth from root canals

NCT ID NCT07751016

Disease control Sponsor: Seoul National University Dental Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This Phase 2 trial tests whether a topical drug called KH001 can preserve the pulp (nerve) inside teeth with deep cavities. Adults with deep dentinal caries will receive either KH001 or a placebo applied to the cavity. The study tracks how many people develop irreversible pulpitis or pulp necrosis, and whether the dentin thickens, to see if KH001 can avoid the need for more invasive treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
KH001, a topical drug applied to deep cavities
What this could lead to
If successful, KH001 could offer a way to treat deep cavities without needing root canals, preserving natural teeth.
What could go wrong
This is an early-stage trial with only 36 participants, so results may not apply broadly. The drug could also cause allergic reactions or fail to prevent pulp damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 36 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Is ≥ 19 years old by the time of the screening visit. * Has signed written informed consent in the study. * Subjects who can comply with oral hygiene during the study period. Exclusion Criteria: * Is allergic to the active ingredient or other ingredients used in the investigational product. * Have participated in another clinical study within 30 days from screening visit and have a history of administration of investigational product. * Is judged by the investigator as ineligible for participation for other reasons.

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Conditions

The condition(s) this trial relates to.

dental caries dentin caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental caries

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Seoul National University Dental Hospital

    Seoul, South Korea

More trials for these conditions

Other studies related to the condition(s) this trial covers.