Ketogenic vs mediterranean diet: which is better for aging bones and muscles?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Postmenopausal * BMI 20 to \<40 kg/m2 * Weight stable for last 12 months * Male or female biological sex * Willing to eat supplied food and adhere to dietary advice * Willing to document food intake * Willing to maintain weight * Willing to attend study visits * Smartphone ownership * Community-dwelling with permanent living arrangement * Resides within 30 miles of Gainesville, FL * Willing to avoid alcohol intake * Estimated energy requirement ≤ 2,700 kcal/day * Have a refrigerator and means to reheat food within dwelling * Bone mineral density tested within past 5 years or U.S. ethnicity-specific fracture risk assessment tool (FRAX) indicates ten year-probability of hip fracture \<3% and ten year-probability of major osteoporotic fracture \<20% Exclusion Criteria: * Pre- or peri-menopausal * Fracture in past 6 months * Circulating 25-hydroxyvitamin D \< 20 ng/mL at screening * History or prevalence of metabolic bone disease * Chronic kidney disease diagnosis or eGFR \<60 mL/min/1.73 m2 at screening * Current or history of cancer excluding non-melanoma skin cancer * Clinical cardiovascular disease, excluding current use of anti-hypertensive medication * LDL cholesterol at screening that is elevated (≥ 160 mg/dL) or uncontrolled (≥ 100 mg/dL despise current statin treatment) * History of recurrent kidney stones * Current diabetes diagnosis * Liver disease * Pancreatic disease * Heavy drinking per CDC definition * Currently smoke tobacco * Malabsorption disease including celiac and inflammatory bowel disease * Inborn error of metabolism including disorders of fatty acid transport or oxidation, organic aciduria, porphyria, or familial hyperlipidemia * Dementia diagnosis * Dietary restrictions including food allergy, vegetarianism, veganism or gluten, dairy, or seafood avoidance * Current or history of diagnosed eating disorder * Thyroid disorder * Male hypogonadism * Menopause before age 40 years * Gender-affirming hormone therapy * Currently eat a ketogenic or Mediterranean diet based on ASA 24-hour dietary recall and Mediterranean diet screener * Participation in concurrent research study * Currently homeless * Presence or possibility of co-morbid condition discovered during medical screening that would elicit safety concerns * Living in skilled nursing facility * Current gallbladder disease including gallstones * History of 2 or more abdominal surgeries * Current chronic constipation * Current chronic diarrhea