Can ancient herbs stop colon polyps from coming back?
NCT ID NCT07505056
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a traditional Chinese medicine herbal formula, Jianpi Lishi Jiedu Granules, can prevent colorectal adenomas (precancerous polyps) from returning after they are removed during a colonoscopy. About 376 adults who recently had such polyps removed will take either the herbal granules or a placebo for 3 months. Researchers will check polyp recurrence rates after one year using a follow-up colonoscopy.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Jianpi Lishi Jiedu Granules (a traditional Chinese medicine herbal formula)
- What this could lead to
- If it works, this could offer a natural way to lower the chance of colorectal polyps coming back after surgery, reducing the need for repeat procedures.
- What could go wrong
- This is an early-stage trial with no results yet, and the herbal granules may not be more effective than placebo. The study is also limited to people with a specific traditional Chinese medicine diagnosis.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 376 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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May 2026
An estimate. Start dates often move.
- Expected to finish
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Feb 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Aged between 18 and 80 years, male or female 2. Have undergone endoscopic resection of colorectal adenoma within the past 2 weeks (cold snare resection or endoscopic mucosal resection for adenomas \< 20 mm, or endoscopic submucosal dissection for adenomas ≥ 20 mm), and have been diagnosed with colorectal advanced adenoma by endoscopy and pathology 3. Traditional Chinese Medicine (TCM) syndrome type conforms to the Spleen Deficiency and Dampness Toxin syndrome 4. The patient is fully informed, voluntarily consents to data collection, and has signed the informed consent form Exclusion Criteria: 1. Patients with diseases such as familial polyposis, inflammatory bowel disease, serrated polyposis syndrome, Peutz-Jeghers syndrome, or other hereditary polyposis syndromes 2. Patients with long-term use of medications such as aspirin, metformin, intestinal flora regulators, folic acid, calcium preparations, and vitamin D 3. Patients with a bleeding tendency (referring to a pathological state where hemostasis is difficult after spontaneous bleeding or minor trauma due to coagulation dysfunction or vascular structural issues) or those currently using anticoagulant medications (e.g., aspirin, clopidogrel) 4. Patients in the active phase of inflammatory bowel disease (such as ulcerative colitis, Crohn's disease, etc.), with a history of intestinal bleeding, or a history of intestinal surgery 5. Patients with high-grade intraepithelial neoplasia involving the vascular system, lymphatic tumor thrombi, or small arteries; patients with biopsy pathology confirming suspected malignancy or established malignancy 6. Pregnant or lactating women, or patients planning a recent pregnancy 7. Patients with an allergic constitution or a history of allergies to multiple drugs 8. Patients with severe heart, brain, lung, liver, kidney diseases, or mental disorders who cannot tolerate colonoscopy, treatment, and clinical intervention 9. Patients currently participating in other clinical trials or those previously involved in trials related to this study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- AI may catch precancerous polyps from simple blood tests
- AI eyes colon polyps: can it spot the dangerous ones?
- Can beans beat obesity and colon cancer?
- Can 3D vision spot hidden polyps better than standard colonoscopy?
- Can a plasma beam stop colon polyps from coming back?