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Plant-Derived heme iron: a new way to fight iron deficiency?

NCT ID NCT07143890

Knowledge-focused Sponsor: ETH Zurich Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how well iron-deficient women absorb iron from two plant-based sources—iron chlorophyllin and soy hemoglobin—compared to standard ferrous sulfate and animal-based heme iron. Forty-five women with low iron stores but not anemic took each type of iron in water or maize porridge. Researchers measured iron absorption in blood after 14 days to see if plant heme could be a good alternative for fortifying foods.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
iron chlorophyllin, soy hemoglobin, ferrous sulfate, porcine hemoglobin
What this could lead to
If plant-derived heme iron is absorbed well, it could lead to better iron fortification in foods, helping prevent iron deficiency without relying on animal sources.
What could go wrong
This is a small, completed experimental study in 45 women, not a treatment trial. Results may not apply to men, children, or people with anemia, and plant heme may not work as well in real-world diets.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

45 people

The number who actually took part.

Started

Sep 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Serum ferritin \< 45 µg/L (iron depleted) * Body weight \< 70 kg * Body mass index 18,5 - 24,9 kg/m2 (normal weight) Exclusion Criteria: * Hb \< 120 g/L (anemia) * CRP \> 5 µg/L (inflammation) * Strict vegan and vegetarians * Any metabolic, gastrointestinal kidney or chronic disease * Consumption of mineral and vitamin supplements since screening and over the study period until last blood sample collection * Blood transfusion over the past 6 months * blood donation over the past 6 months * Significant blood loss (accident, surgery) over the past 6 months * Women who are pregnant or breast feeding * Smoker (\> 1 cigarette per week) * Continuous/long-term use of medication (except for contraceptives) * Therapeutic iron infusion over the past 6 months, * Known hypersensitivity or allergy to iron supplements, * Intention to become pregnant during the course of the studies, * Known or suspected non-compliance, drug or alcohol abuse, * Inability to follow the procedures of the studies, e.g. due to language problems, psychological disorders, dementia, etc. of the participant, * Participation in another study with investigational drug within the 30 days preceding and during the present studies, * Enrolment of the investigator, his/her family members, employees and other dependent persons

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Conditions

The condition(s) this trial relates to.

Iron Deficiencies iron deficiency anemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Iron absorption Iron deficiency (ID)

Contacts and locations

Locations

  • ETH Zurich, Laboratoy of Clinical Biopharmacy

    Zurich, 8092, Switzerland

More trials for these conditions

Other studies related to the condition(s) this trial covers.