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Knee surgery painkiller linked to catheter need – new trial seeks safer option

NCT ID NCT07050277

Symptom relief Sponsor: University of Toronto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether skipping intrathecal morphine during knee revision surgery can lower the chance of needing a catheter for urinary retention. Fifty adults having non-infected knee revision will get either morphine or a placebo alongside standard nerve blocks. The goal is to see if pain control stays good while avoiding bladder complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Intrathecal morphine
What this could lead to
If successful, this could show that skipping intrathecal morphine during knee revision surgery lowers the risk of needing a catheter without worsening pain.
What could go wrong
This is a small, early-phase trial with only 50 participants, so results may not apply to everyone. The study is still recruiting, and the outcome is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Non pregnant patients undergoing unilateral non infected rTKA surgery; * Older than 21 years of age, with American Society of Anesthesiologists (ASA) physical status I-III; * With no alcohol or drug dependency history; * With sufficient understanding and co-operation about the usage of a perineural catheter for pain management; body mass index (BMI) under 45; * With no allergy to medications used in the study protocol (bupivacaine, lidocaine, ropivacaine, midazolam, propofol, ketamine, morphine, hydromorphone, fentanyl, acetaminophen, celecoxib, ondansetron, dexamethasone, tranexamic acid); * No current or recent use of opioids (within the last 2 weeks) in an average oral morphine equivalent (OME) of 20 mg/day or higher; * With no contra-indications for neuraxial anesthesia, IPACK block, ACB and adductor canal catheter insertion; * Who speak and understand the English language; * Who agrees to participate on this study through the signature of the consent form. Exclusion Criteria: * Patients will be excluded of the study if they have a failed spinal anesthesia and needs for a conversion to general anesthesia; * If peripheral nerve blocks are not possible to be performed due to technical difficulties; * If during patient's care a deviation of the protocol occurs; * If CACB catheter has issues on its function, disconnects or exteriorizes within the first 48 hours of infusion; * Or if patient decides to withdraw from the study.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia, spinal Arthroplasties, knee replacement Nerve block Urinary retention postoperative

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Mount Sinai Hospital

    RECRUITING

    Toronto, Ontario, M5G 1X5, Canada

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