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Sleep hormone and skin gel join forces to fight wisdom tooth pain

NCT ID NCT07735806

Symptom relief Sponsor: Kafrelsheikh University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Sep 09, 2026 · Updated 5 times

Summary

This trial tests whether placing a gel containing hyaluronic acid and melatonin into the socket after impacted wisdom tooth removal can reduce pain, swelling, and speed bone healing. Forty adults aged 18–35 will receive either the active gel or a plain gel foam. Pain and swelling are checked at days 1, 3, and 7, and bone density is measured with a CT scan at 6 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a topical gel containing 0.2% hyaluronic acid and 3 mg melatonin
What this could lead to
If it works, this could offer a simple, low-cost way to improve recovery after wisdom tooth surgery.
What could go wrong
This is a small, early-stage trial with only 40 participants, so results may not apply to everyone. The mixture is applied locally, so its effects may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Jul 2024

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18-35 years. * patients requiring surgical extraction of impacted mandibular third molars classified as Pell and Gregory class II, position B, irrespectiver of the impaction type. * Patients with normal moueh opening at the time of extraction. * Surgical site free of active infections. * Patients free from systemic diseases that may affect the healing process. * Patients without known allergy for melatonin, local anesthetic agents, amoxicillin, or acetaminophen (paracetamol ) . Exclusion Criteria: * Heavy smokers (\>cigarettes / day) . * Pregnant patients. * Patients with local infections ('e.g pericoronitis) . * Patients who used melatonin for more than 6 months prior to the study. * Patients with poor oral hygiene or active periodontal disease. * Patients with limited mouth opening * Surgical procedures exceeding 30 minutes.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Impacted mandibular third molar

Contacts and locations

Locations

  • Faculty of Dentistry, Kafrelsheikh University

    Kafr ash Shaykh, Kafr el-Sheikh Governorate, 33511, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.