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Saliva enzyme may reveal hidden healing clues after wisdom tooth removal

NCT ID NCT07600619

Knowledge-focused Sponsor: Hasanuddin University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a natural enzyme in saliva, called alpha-amylase, can help doctors see how well the mouth heals after wisdom tooth surgery. Twenty-eight adults had their impacted wisdom teeth removed. Half received a special blood-based clot (PRF) in the socket to help healing, while the other half got standard care. Saliva samples were taken right after surgery and again on days 3 and 7. The goal was to see if the enzyme levels changed differently between the two groups, which could lead to a simple, painless way to track healing in the future.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

28 people

The number who actually took part.

Started

May 2024

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18-35 years. * Patients requiring surgical extraction of impacted mandibular third molars. * Patients classified as American Society of Anesthesiologists Physical Status Classification class I or II. * Patients who are willing to participate and provide written informed consent. * Patients able to comply with study procedures and follow-up visits. Exclusion Criteria: * Patients with systemic diseases that may affect wound healing or inflammatory response (e.g., Diabetes Mellitus, immunodeficiency disorders). * Patients currently using anti-inflammatory drugs, corticosteroids, or antibiotics within the last 7 days before surgery. * Patients with active oral infection or severe periodontal disease at the surgical site. * Patients with a history of smoking or tobacco use. * Pregnant or breastfeeding women. * Patients with salivary gland disorders or conditions affecting salivary secretion. * Patients with known bleeding disorders or currently receiving anticoagulant therapy. * Patients with allergy or contraindication to materials or medications used during the procedure.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Impacted mandibular third molar Platelet-rich fibrin (PRF) Postoperative wound healing Salivary alpha amylase

Contacts and locations

Locations

  • Dental Hospital of Hasanuddin University

    Makassar, South Sulawesi, Indonesia

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