Sleep hormone and skin gel join forces to fight wisdom tooth pain

NCT ID NCT07735806

Completed Symptom relief Sponsor: Kafrelsheikh University Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Aug 12, 2026 · Updated 3 times

Summary

This trial tests whether placing a gel containing hyaluronic acid and melatonin into the socket after impacted wisdom tooth removal can reduce pain, swelling, and speed bone healing. Forty adults aged 18–35 will receive either the active gel or a plain gel foam. Pain and swelling are checked at days 1, 3, and 7, and bone density is measured with a CT scan at 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a topical gel containing 0.2% hyaluronic acid and 3 mg melatonin
What this could lead to: If it works, this could offer a simple, low-cost way to improve recovery after wisdom tooth surgery.
What could go wrong: This is a small, early-stage trial with only 40 participants, so results may not apply to everyone. The mixture is applied locally, so its effects may be modest.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IMPACTED MANDIBULAR THIRD MOLAR

Contacts and locations

Locations

Faculty of Dentistry, Kafrelsheikh University

Kafr ash Shaykh, Kafr el-Sheikh Governorate, 33511, Egypt

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