Tooth-Derived graft may boost jaw bone healing after cyst removal

NCT ID NCT07652216

Ongoing Disease control Sponsor: Jagiellonian University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether using a patient's own tooth-derived bone graft (ADDM) combined with a platelet-rich fibrin (A-PRF) can improve bone healing after removing a dentigerous cyst and an impacted wisdom tooth. Thirty-five adults with this condition will receive either standard care (blood clot), A-PRF alone, or A-PRF plus ADDM. The main goal is to measure bone defect reduction on CT scans at 6 and 12 months, with pain as a secondary outcome.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Autogenous Demineralized Dentin Matrix (ADDM) and Advanced Platelet-Rich Fibrin (A-PRF)
What this could lead to: If successful, this approach could speed up bone regeneration and reduce pain after jaw cyst surgery, offering a better recovery option.
What could go wrong: This is a small, early-stage study with only 35 participants, so results may not apply to everyone. The treatments are experimental and may not improve healing over natural blood clot formation.

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Conditions

The condition(s) this trial relates to.

dentigerous cyst

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOGENOUS DENTIN GRAFT BONE REGENERATION DEMINERALIZED DENTIN MATRIX DENTIGEROUS CYST DENTIN MATRIX IMPACT MOLAR IMPACTED LOWER THIRD MOLAR IMPACTED MANDIBULAR THIRD MOLAR MANDIBLE CYST PLATELET RICH FIBRIN

Contacts and locations

Locations

Department of Oral Surgery, Institute of Dentistry, Jagiellonian University Medical College

Krakow, Malopolska, 31-155, Poland

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