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Could a ketamine cousin replace opioids for pain?

NCT ID NCT07504601

First seen Apr 02, 2026 · Last updated Jun 19, 2026 · Updated 14 times

Summary

This study tests whether a single dose of (2R,6R)-HNK, a drug related to ketamine, can reduce short-term pain in healthy adults aged 18-60. Participants will receive either the drug or a placebo and undergo pain tests, blood draws, and brain scans. The goal is to find a safer, non-addictive alternative to opioids for acute pain.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.