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Oxygen chamber may boost knee surgery recovery

NCT ID NCT06493851

Symptom relief Sponsor: Assaf-Harofeh Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people recover faster after anterior cruciate ligament (ACL) knee surgery. Forty adults aged 18-45 who need ACL reconstruction will be randomly assigned to receive either 30 sessions of HBOT over 6 weeks or standard care. The main goal is to see if HBOT improves knee function and symptoms, measured by a standard knee score, over the following months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hyperbaric oxygen therapy (device)
What this could lead to
If it works, this could offer a way to recover faster and with better knee function after ACL surgery.
What could go wrong
This is a small, early-stage trial with only 40 people. The treatment requires many sessions and may not work for everyone. There are also risks like ear or sinus pain from pressure changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Subjects willing and able to read, understand and sign an informed consent 2. Age 18-45 3. Anterior cruciate ligament tear for reconstruction (with or without meniscal repair). Exclusion Criteria: 1. Inability to attend scheduled clinic visits and/or comply with the study protocol 2. Additional injury 3. An inability to perform MRI. 4. Active malignancy 5. Chest pathology incompatible with pressure changes (including active asthma) 6. Ear or sinus pathology incompatible with pressure changes 7. History of epilepsy 8. Claustrophobia 9. Previous knee surgery 10. Participation in another study

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior cruciate ligament reconstruction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The Sagol Center for Hyperbaric Medicine and Research Shamir Medical Center (Assaf Harofeh)

    RECRUITING

    Zrifin, 70300, Israel

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