Green tea extract shows promise for gut health in metabolic syndrome
NCT ID NCT03973996
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether taking green tea extract for one month could improve gut health and reduce inflammation in people with metabolic syndrome and in healthy adults. Participants took either the extract or a placebo for a month, then switched. The study measured markers of inflammation and gut barrier function in blood and urine.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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46 people
The number who actually took part.
- Started
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Jul 2019
- Finished
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Mar 2021
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: Individuals with ≥3 of the following established criteria for metabolic syndrome: * Fasting glucose 100-126 mg/dL * Waist circumference \>89/\>102 cm for females/males * HDL-C \<50/\<40 mg/dL for females/males * Triglyceride \>150 mg/dL * Blood pressure \>130/85 mmHg Healthy adults: * Body weight 19-25 kg/m2 * Fasting glucose \<100 mg/dL * HDL-C \>50/\>40 mg/dL for females/males * Triglyceride \<150 mg/dL * Blood pressure \<120/80 mmHg Exclusion criteria: * Concurrent tea consumption * Use of dietary supplements, prebiotics, or probiotics * Use of antibiotics or antiinflammatory agents * History of liver disease, cardiovascular disease, hypertension (blood pressure \>140/90 mmHg), or cancer * History of gastrointestinal disorders, chronic diarrhea, or surgeries * Hemochromatosis * Parkinson's disease * Use of medications to manage diabetes, hypertension, or hyperlipidemia * Use of antipsychotic medications \[Clozapine, lithium, Diazepam\] * Use of blood thinning medications \[Warfarin\] * Use of high blood pressure medications \[nadolol\] * Use of monoamine oxidase inhibitors \[selegiline\] * Alcohol consumption \>2 drinks/d * Smoking tobacco * Vegetarian * Pregnancy, lactation, or recent changes in birth control use for women
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Ohio State University
Columbus, Ohio, 43210, United States
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Other studies related to the condition(s) this trial covers.
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