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New gel could stop tooth pain after fillings

NCT ID NCT07188142

Symptom relief Sponsor: Beenish Hassan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether applying Gluma desensitizer before a filling can reduce tooth sensitivity afterward. Sixty adults with cavities in their back teeth will be randomly assigned to get either the desensitizer plus a standard filling or just the standard filling. Their pain response to an air puff will be measured right after the procedure and again at 1 week, 1 month, and 3 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Gluma Desensitizer (glutaraldehyde/HEMA solution)
What this could lead to
If it works, this could give dentists a simple way to reduce tooth pain after fillings, making the procedure more comfortable for patients.
What could go wrong
This is a small, early-stage trial with only 60 participants, so results may not apply to everyone. The treatment is for temporary sensitivity, not a cure for tooth decay.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18-45 years. * Good oral hygiene. * Active primary class I carious lesions on vital molar teeth with ICDAS score 3 * Patients complaining of sensitivity to air and osmotic stimulus. * Teeth having a positive cold test. * No signs of pulp inflammation or spontaneous pain before treatment. Exclusion Criteria: * Excessive tooth wear due to clenching or abnormal habits. * Traumatic occlusion. * Periodontal or gingival disease. * Patients using analgesics and/or anti-inflammatory medicine.

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Conditions

The condition(s) this trial relates to.

dental caries dentin sensitivity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental caries Dentin hypersensitivity Post-operative sensitivity Post-operative sensitivity after class I composite restorations Tooth sensitivity after composite restorations

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Margalla Institute of Health Sciences Quaid e Azam Avenue, Gulraiz phase 3, Gulraiz Housing Scheme, Rawalpindi

    Rawalpindi, Punjab Province, Pakistan

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