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New nerve block combo may cut opioid use after ACL repair

NCT ID NCT05720949

Symptom relief Sponsor: Hospital for Special Surgery, New York Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding genicular nerve blocks to standard pain blocks could reduce opioid use and pain after ACL knee surgery. 192 adults having outpatient ACL repair were randomly assigned to get the extra blocks or standard care. The goal was to see if the new approach lowers opioid consumption, pain scores, and helps patients go home sooner.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

192 people

The number who actually took part.

Started

Jan 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 - 80 * English speaking * American Society of Anesthesiologists (ASA) I - III * BMI \< 35 * Scheduled for ambulatory arthroscopic unilateral anterior cruciate ligament repair surgery with bone tendon bone autograft Exclusion Criteria: * History of chronic pain syndromes * Chronic opioid use (daily morphine milligram equivalents \> 30 mg for at least 3 months) * Contraindication to peripheral nerve blocks * Contraindication to neuraxial anesthesia * History of peripheral neuropathy or pre-existing neurological deficits * Psychiatric or cognitive disorder that prohibit patient from following study protocol * Allergy to local anesthetic or study medications * Multi-ligament surgery * History of substance abuse * Infection at the site of injection * diagnoses of Type I or Type II diabetes

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACL Anterior cruciate ligament injuries

Contacts and locations

Locations

  • HSS Sports Medicine Institute West Side

    New York, New York, 10019, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.