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Could a Parent's hamstring tendon rebuild a Child's torn ACL?

NCT ID NCT05395767

Disease control Sponsor: Maidstone & Tunbridge Wells NHS Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial is testing whether using a hamstring tendon from a parent can safely and effectively reconstruct a torn anterior cruciate ligament (ACL) in children and teenagers whose bones are still growing. The study will enroll 40 patients aged 8 to 17 with ACL tears that need surgery. The parent donates one of their hamstring tendons, which is then implanted into the child during arthroscopic knee surgery. Researchers will track knee function, symptoms, and ability to return to sports for up to two years after the procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
living donor hamstring allograft from a parent
What this could lead to
If successful, this approach could offer children with ACL tears a reliable graft option that avoids the risks of using their own tissue.
What could go wrong
This is a small, early-stage study with only 40 participants. The donor surgery carries its own risks, and long-term outcomes are not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2021

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

8 to 17 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 8 to 17 years inclusive and have a clinically and radiologically confirmed ACL rupture that requires reconstruction. * Patients who have had previous surgery for meniscal pathology . * Patients with current meniscal pathology * The child and their responsible adult are in agreement with the choice to undergo anterior cruciate ligament reconstruction using living donor allograft. * Donors has not previously undergone tendon harvest on the chosen donor limb * Patients are willing to attend follow up appointments and agree to fill in knee questionnaires and allow instrumented knee ligament testing. Exclusion Criteria: * Patients who have previously undergone ACL surgery on the same limb (and therefore require revision surgery) * Patients who are immunosuppressed, or receiving immunosuppressive therapy * Patients who are unable to attend follow-up appointments for continued research purposes. * Donors who have previously undergone hamstring tendon surgery on the donor limb * Patients and donors who have a positive screening blood test for any of the transmissible infections tested * Donors whose answers to the 'Donor Documentation Questionnaire' indicate that there could be a risk of transmissible infection, may not included * Donors who are not considered healthy enough to undergo a tenotomy under General anaesthetic

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Conditions

The condition(s) this trial relates to.

anaplastic large cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACL

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Trauma & Orthopaedic Dept, Tunbridge Wells Hospital

    RECRUITING

    Pembury, Kent, TN2 4QJ, United Kingdom

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