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Eye injection shows promise against fungal ulcers

NCT ID NCT02731638

Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding an injection of the antifungal drug voriconazole into the eye could improve treatment for fungal corneal ulcers. 70 people with moderate to severe infections received either standard antifungal drops alone or drops plus three injections over 10 days. The goal was to see if the injection helped clear the fungus faster.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
voriconazole injection plus natamycin drops
What this could lead to
If successful, this approach could become a standard treatment for fungal eye infections, reducing the need for more invasive procedures.
What could go wrong
This is a single, completed trial with 70 participants. The results may not apply to all types of fungal infections or to patients with more severe disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

70 people

The number who actually took part.

Started

Sep 2016

Finished

Jul 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Moderate to severe corneal ulcer that is smear positive for filamentous fungus * Pinhole visual acuity worse than 20/70 in affected eye * Basic understanding of the study as determined by the physician * Commitment to return for follow up visits Exclusion Criteria: * Gram stain positive for bacteria or evidence of other concomitant infection (i.e. herpes, acanthamoeba) * Impending or frank perforation at recruitment * Involvement of sclera at presentation * Non-infectious or autoimmune keratitis * History of corneal transplantation or recent intraocular surgery * No light perception in the affected eye * Pinhole visual acuity worse than 20/200 in the unaffected eye * Pregnant women * Participants who are decisionally and/or cognitively impaired

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Conditions

The condition(s) this trial relates to.

corneal disorder corneal ulcer fungal keratitis keratitis ulcer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Corneal ulcer Fungal keratitis

Contacts and locations

Locations

  • Aravind Eye Hospitals

    Pondicherry, Tamil Nadu, India

  • Francis I. Proctor Foundation at UCSF

    San Francisco, California, 94143, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.