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Glow-in-the-dark dye could help surgeons save tiny glands during thyroid surgery

NCT ID NCT06169735

Disease control Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a fluorescent dye called indocyanine green can help surgeons find and protect the parathyroid glands during thyroid or parathyroid surgery. The dye is injected into the bloodstream and makes the glands glow under a special camera. The trial enrolled 417 adults but was terminated early, so the full results are not available.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Indocyanine green (a fluorescent dye injected into the bloodstream)
What this could lead to
If it works, this technique could help surgeons better identify and preserve parathyroid glands during thyroid surgery, reducing complications.
What could go wrong
The trial was terminated early, so results are limited. The dye may not work for everyone, and some people cannot receive it due to allergies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

417 people

The number who actually took part.

Started

Apr 2024

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age greater than 18 years old Exclusion Criteria: * Patients with iodine or shellfish allergies would be excluded. * Patients with allergy to indocyanine green. * Pregnancy

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Conditions

The condition(s) this trial relates to.

adenoma parathyroid gland adenoma parathyroid gland disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adenoma Parathyroid dysfunction

Contacts and locations

Locations

  • UAB Callahan Eye

    Birmingham, Alabama, 35233, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.