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Pedal or pump: study tests best exercise to slow memory decline

NCT ID NCT07600034

Symptom relief Sponsor: Universiti Sains Malaysia Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how different types of exercise—cycling or strength training—affect brain function and physical frailty in older adults with mild cognitive impairment (MCI), an early stage of memory loss. About 36 people aged 60 to 85 with MCI will be randomly assigned to 12 weeks of exercise or a control group. Researchers will measure changes in brain blood flow, thinking skills, and physical abilities before, after, and 4 weeks following the program.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 36 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: 1. males and females aged 60 until 85 2. living in the community, 3. confirmed diagnosis of MCI 4. able to walk without assistance for at least two minutes, 5. able to participate in exercise intervention screened by a physician based on ACSM guidelines Exclusion criteria: 1. uncertain diagnosis of MCI, 2. did not screen for ability to participate in exercise intervention, 3. presence of other neurological, psychiatric, or cognitive impairment disorders, 4. seriously ill, presence of Hepatitis B or C, cancer, and patients on immunosuppressant drugs, 5. type 2 diabetes mellitus, 6. uncontrolled hypertension or hypotension (systolic blood pressure \>160 mm Hg and/or diastolic blood pressure \>100 mm Hg at rest), 7. unstable cardiac, renal, lung, liver, or other severe chronic disease, 8. history of myocardial infarction and/or stroke within previous year, 9. vision/hearing disorder, 10. musculoskeletal disorders that affect physical function such as osteoporosis, severe knee osteoarthritis, and degenerative spinal condition, 11. presence of any major psychiatric disorder (a clinical diagnosis of major depressive disorder, bipolar or schizophrenia) 12. history of vitamin B12 deficiency or hypothyroidism (stable treatment for at least 3 months is allowed) 13. serious or non-healing wound, ulcer, or bone fracture

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mild cognitive impairment (MCI)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National Institute of Education

    Singapore, 637616, Singapore

More trials for these conditions

Other studies related to the condition(s) this trial covers.