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One hour of exercise may sharpen aging brains, study hints

NCT ID NCT05853913

Knowledge-focused Sponsor: Rutgers, The State University of New Jersey Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how one session of moderate-to-hard walking or jogging changes the brain's response to insulin in adults aged 40 to 80 who are overweight or obese. Researchers will use MRI scans to measure brain insulin sensitivity and also test memory, thinking, and heart health. The goal is to understand how exercise might lower dementia risk by improving brain function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Exercise (walking/jogging at moderate-to-hard intensity for 1 hour)
What this could lead to
If successful, this could reveal how exercise improves brain health and insulin function, potentially guiding future strategies to reduce dementia risk.
What could go wrong
This is a small, early-stage study with only 16 participants, so results may not apply broadly. It tests only a single exercise session, not long-term effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

16 people

The number who actually took part.

Started

May 2023

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female \>/=40 and \</=80 years old. * Has a body mass index \>/=25 and \</=45 kg/m2. * Physical Activity (\<150 min of moderate/high intensity exercise per week) Exclusion Criteria: * Subjects who have not been weight stable (\>2 kg weight change in past 3 months) * Subjects who are smokers or who have quit smoking \<1 years ago * Subjects with abnormal estimated glomerular filtration rate (eGFR). * Hypertriglyceridemic (\>400 mg/dl) and hypercholesterolemic (\>260 mg/dl) subjects * Hypertensive (\>160/100 mmHg) * Subjects with a history of significant metabolic, cardiac, congestive heart failure, cerebrovascular, hematological, pulmonary, gastrointestinal, liver, renal, or endocrine disease or cancer that in the investigator's opinion would interfere with or alter the outcome measures or impact subject safety. * Pregnant (as evidenced by positive urine pregnancy test) or nursing women * Subjects with contraindications to participation in an exercise * Current Pregnancy * Currently taking active weight suppression medication (e.g. phentermine, orlistat, lorcaserin, naltrexone-bupropion in combination, liraglutide, benzphetamine, diethylpropion, phendimetrazine) * Subjects currently taking medications that affect heart rate and rhythm (i.e. Ca++ channel blockers, nitrates, alpha- or beta-blockers). * Known contraindications for MRI imaging

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Conditions

The condition(s) this trial relates to.

cognitive disorder Insulin Resistance Motor Activity Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Cardiovascular disease risk Cognition Insulin resistance Obesity

Contacts and locations

Locations

  • Center for Advanced Human Brain Imaging Research

    Piscataway, New Jersey, 08854, United States

  • Institute for Food, Nutrition, and Health

    New Brunswick, New Jersey, 08901, United States

  • Robert Wood Johnson University Hospital Clinical Research Center

    New Brunswick, New Jersey, 08901, United States

  • Rutgers University Loree Gymnasium

    New Brunswick, New Jersey, 08901, United States

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