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Colon polyp showdown: which removal method wins?

NCT ID NCT03962868

Disease control Sponsor: University Hospital, Limoges Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two procedures for removing large, flat colon polyps (over 25 mm) in 360 adults. One method, ESD, removes the polyp in one piece but has higher risks and costs. The other, EMR, removes it in pieces but is safer and cheaper. The goal was to see which leads to fewer polyps coming back and which is more cost-effective over 3 years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

360 people

The number who actually took part.

Started

Sep 2019

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient suffering from non-pedunculated polyp suspected larger than 25 mm in the colon * Colon localization beyond 15 cm of the anal margin. * Indication for endoscopic treatment * Patients aged ≥ 18 years old * Patients able to fill in questionnaires written in French Exclusion Criteria: * Prior endoscopic resection attempt * Contra-indication to colonoscopy * Contra-indication to general anesthesia * Inability to stop antiplatelet agents and anti-coagulant according to the European Society of Gastro-Intestinal Endoscopy guidelines. * Recurrent adenoma: post-endoscopic or surgical resection * Pregnant or lactating women * Genetic polyposis (Familial Adenomatous Polyposis, Lynch Syndrome, Peutz-Jeghers Syndrome) * Inability to provide informed consent * Patient under legal protection and or deprived of liberty by judicial or administrative decision * Patient already participating in an interventional clinical research protocol * Patient who cannot be followed for the duration of the study * Non-pedunculated polyp ≤ 25 mm * More than one lesion \> 25 mm that fulfilled the inclusion criteria * Suspicion of deep submucosal cancer by analysis of macroscopic appearance (Paris 0-III), vascular pattern and pit pattern (SANO IIIB, KUDO Vn) * Non granular pseudodepressed Laterally spreading tumors due to the high risk of nonvisible submucosal cancer * Polyp involving the appendice deeply (type 2 or 3 of classification of Toyonaga) * Polyp inside the ileo-caecal valvula * Tattoing under the lesion * Inflammatory Bowel Disease with expected fibrosis (Crohn disease or ulcerative colitis) * Colon localization \< 15 cm of the anal margin. * Polyp invading a diverticulum * Pedunculated polyp * Absence of lesion

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Conditions

The condition(s) this trial relates to.

colon adenoma polyp of colon

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colonic polyp

Contacts and locations

Locations

  • Cochin Hospital

    Paris, 75014, France

  • Edouard Herriot Hospital

    Lyon, 69437, France

  • Jean Mermoz Hospital

    Lyon, France, 69008, France

  • Nancy University Hospital

    Nancy, 54500, France

  • Pontchaillou Hospital

    Rennes, 35033, France

  • University Hospital, Limoges

    Limoges, France, 87042, France

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