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Nighttime seizures and dreams: new study probes the link

NCT ID NCT07605858

Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how epileptic brain activity during sleep can cause awakenings and change dream recall or content. Researchers will use tiny electrical pulses in the brain during sleep to trigger mild epileptic activity and observe the effects. The goal is to better understand the connection between epilepsy, sleep disruption, and dreaming in 20 adults with drug-resistant focal epilepsy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Direct electrical stimulation (DES) during sleep
What this could lead to
If successful, this could help doctors understand how nighttime seizures disrupt sleep and dreams, potentially guiding treatments to improve sleep quality in epilepsy patients.
What could go wrong
This is a small, early-stage study with only 20 participants, so results may not apply to everyone. It is designed to gather knowledge, not to test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients investigated with SEEG as part of presurgical evaluation in the Department of Functional Neurology and Epileptology of the HCL, Lyon, France and in the Epilepsy Department, Duke University Hospital, Durham, USA.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Written informed consent obtained from study subject and ability for study subject to comply with the requirements of the study * Aged 18 to 55 years old * Diagnosis of focal temporal or frontal lobe epilepsy based on non-invasive work-up * Epilepsy is refractory to treatment, as defined by the International League Against Epilepsy 31 * Patients undergoing SEEG investigation * At least 1 frontal and 1 temporal electrode in the SEEG procedure * Patient affiliated to the French health care system Exclusion Criteria: * Multifocal epilepsy * Untreated severe obstructive sleep-apnea syndrome * Too abnormal SEEG recording interfering with sleep stage identification during the DES procedure * Severe cognitive impairment preventing full understanding and completion of the protocol * Unstable psychiatric condition * Subject participating in other interventional research with an exclusion period still in progress at pre-inclusion * Persons deprived of their liberty by a judicial or administrative decision * Adults subject to a legal protection measure (guardianship, curatorship * Persons not affiliated to a social security scheme or beneficiaries of a similar scheme

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Conditions

The condition(s) this trial relates to.

epilepsy focal epilepsy frontal lobe epilepsy temporal lobe epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Patients with drug-resistant focal epilepsy Seeg as part of presurgical evaluation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Epilepsy Department, Duke University Hospital

    NOT_YET_RECRUITING

    Durham, North Carolina, 27710, United States

  • Service de Neurologie Fonctionnelle et d'Epileptologie Hôpital Neurologique, GHE, Hospices Civils de Lyon Hôpital Neurologique Pierre WERTHEIMER

    RECRUITING

    Bron, 69500, France

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