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E-Hookah nicotine may damage blood vessels, small study suggests

NCT ID NCT04133376

Knowledge-focused Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether nicotine in electronic hookah (e-hookah) affects blood vessel function. Thirty-three healthy young adults who already used hookah or e-cigarettes vaped e-hookah with or without nicotine in separate sessions. Researchers measured blood vessel dilation and other markers of vascular health before and after vaping. The goal was to see if nicotine alone causes the blood vessel damage seen with e-hookah use.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
electronic hookah vaping with or without nicotine
What this could lead to
If successful, this could clarify whether nicotine in e-hookah harms blood vessels, helping guide future regulations or safer product design.
What could go wrong
This is a small, early-stage study (33 people) that only measures short-term effects. Results may not apply to long-term use or to older or less healthy people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

33 people

The number who actually took part.

Started

Jan 2020

Finished

May 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 39 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 21-39 years old hookah smokers: smoked hookah \>12x in last 12 months * 21-39 years old e-cigarette users: vaped \>12x in last 12 months * no history of illicit drugs * no evidence of cardiopulmonary disease by history/ physical * no diabetes: fasting blood glucose \<100 mg/dl * BP\<140/90mmHg * resting HR\<100 bpm * BMI\<30kg•m2 * no prescription medication Exclusion Criteria: * exhaled CO\>10 ppm (smoking non-abstinence) * positive pregnancy test * psychiatric illness

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Conditions

The condition(s) this trial relates to.

Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endothelial dysfunction Smoking

Contacts and locations

Locations

  • University of California, Los Angeles

    Los Angeles, California, 90024, United States

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Other studies related to the condition(s) this trial covers.