Marfan study sheds light on spinal issues linked to dural ectasia
NCT ID NCT05123339
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times
Summary
This study looked at 90 adults with Marfan syndrome to compare spinal symptoms and daily limitations between those who have dural ectasia (a widening of the spinal sac) and those who do not. Researchers used questionnaires to measure pain, activity limits, and quality of life. The goal was to better understand how dural ectasia affects people with Marfan syndrome.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors better identify and manage spinal symptoms in Marfan patients with dural ectasia.
- What could go wrong
- This is a small, completed observational study, so it cannot prove cause and effect or lead directly to new treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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90 people
The number who actually took part.
- Started
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Feb 2022
- Finished
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Sep 2022
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients screened and selected at the CNMR at Bichat Hospital will receive a letter containing the information note and a self-questionnaire to complete. Patients can reach Dr Troussier by phone or email to ask any questions. Patients will return a copy of the completed briefing note and self-questionnaire by post. In the event of the presence of dural sac ectasia, patients will also be asked to send in the reply letter a copy of an imaging report, MRI or lumbar CT or TAP, or failing that an account- medical report mentioning this presence.
- Ages
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18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Marfan disease according to the Ghent criteria revised in 2010 * Patients followed at the CNMR in Bichat * Adults ≥18 years old and ≤ 55 years old (to limit the incidence of degenerative lumbar pathologies) * Patient not opposing the research * Mastery of the French language Exclusion Criteria: * History of lumbar surgery \<1 year * Specific pathologies of the spine (tumor, infection, trauma, fracture, inflammatory rheumatism) * Inability to write, read or speak French * Cognitive or behavioral problems making assessment impossible * Patients receiving AME * Patients under tutorship or curatorship
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CNMR Bichat
Paris, IDF, 75018, France
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