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Heart surgery study questions routine use of ultrasound probe

NCT ID NCT06154265

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether using a heart ultrasound probe (TEE) during low-risk coronary artery bypass surgery should be done routinely or only when needed. Researchers enrolled 40 patients and checked if it was possible to randomly assign them to one of two groups. The goal is to better understand when TEE is helpful and when it might be unnecessary.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transesophageal echocardiography (TEE) ultrasound probe
What this could lead to
If successful, this could help guide when TEE is truly needed during heart bypass surgery, potentially reducing unnecessary procedures and risks.
What could go wrong
This is a very small, early feasibility study with only 40 participants, so results may not apply to all patients or settings. It does not test a new treatment or cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Jan 2024

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Scheduled to undergo isolated CABG surgery at a hospital within the UPenn Health System 2. Age ≥18 years 3. Ejection fraction ≥50% 4. Transthoracic echocardiography within one year of scheduled surgery date 5. Left heart catheterization within one year of scheduled surgery date 6. English language fluency or facilitated via language interpreter 7. Able to provide informed consent either in English or via a language interpreter 8. Willing to comply with all study procedures Exclusion Criteria: 1. Documented valve (aortic, mitral, tricuspid, or pulmonic) disease (stenosis or regurgitation) moderate or greater. 2. Any CABG surgery with either "possible" or "definite" aortic intervention listed as a planned part of the procedure. plan for either definite or possible surgical intervention. 3. Any CABG surgery with either "possible" or "definite" valve repair/replacement listed as a planned part of the procedure. 4. Having undergone any previous cardiac surgeries (i.e. scheduled with a "REDO" modifier). 5. Proximal/critical left main coronary disease (e.g. greater than or equal to 90% stenosis). 6. Preexisting anomalous coronary arteries 7. Preexisting end-stage renal disease on hemodialysis 8. Preexisting chronic kidney disease (CKD) stage 3, 4, or 5 9. Stroke with residual focal neurological deficit(s) within 90 days of surgery 10. Any of the following presurgical, mechanical circulatory support devices: 1. Intraaortic balloon pump 2. Percutaneous right ventricular assist device (RVAD) 3. Impella 4. Extracorporeal membrane oxygenation (ECMO) 11. Absolute contraindication to echocardiography defined as one or more of the following documented conditions: 1. Esophagectomy 2. Esophagogastrectomy 3. Esophageal trauma 12. Any of these three relative contraindication to TEE: 1. Esophageal varies 2. Gastric bypass surgery 3. Descending thoracic aortic aneurysm 13. Severe pulmonary hypertension defined as: 1. Pulmonary arterial pressure ≥60 mmHg 2. Pulmonary vascular resistance (PVR) ≥3 Woods Units 14. Hemodynamic instability after induction and following placement of an endotracheal tube will be defined as one or more of the following events or scenarios: 1. Placement of an intraaortic balloon pump (IABP) 2. Initiation of venoarterial extracorporeal membrane oxygenation (VAECMO) 3. Placement of a right or left percutaneous mechanical circulatory support device 4. Initiation of epinephrine infusion at a dose ≥ 6 mcg/min for a duration ≥5 minutes 5. Initiation of norepinephrine at a dose ≥8 mcg/min for a duration ≥ minutes 6. Initiation of phenylephrine infusion at a dose ≥100 mcg/min for a duration ≥ minutes 7. Initiation of vasopressin infusion at a dose ≥0.04 units/min for a duration ≥ minutes

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

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Other studies related to the condition(s) this trial covers.