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Dairy fat and fermentation: surprising effects on gut bugs and heart risk?

NCT ID NCT05840081

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how full-fat and fat-free milk and yogurt affect the gut microbiome and heart disease risk factors. 37 adults over 50 drank specially prepared dairy drinks for a period. Researchers measured changes in gut bacteria, metabolic byproducts, and blood markers to see if fat content or fermentation makes a difference. The goal is to improve dietary advice for heart health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Milk or yogurt beverage
What this could lead to
If successful, this could help refine dietary guidelines for heart disease prevention by clarifying how dairy fat and fermentation affect gut health and heart risk.
What could go wrong
This is a small, completed study (37 participants) that measures biomarkers, not clinical outcomes. Results may not apply to younger people or those with different diets.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

37 people

The number who actually took part.

Started

Oct 2023

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age \>50 years 2. Men and postmenopausal women 3. BMI \>25 and \<35 kg/m2 4. No milk allergy, lactose intolerance or adherence to vegan or other dietary pattern that excludes dairy products 5. Non-smoker 6. Usual pattern of bowel movements at least every other day. Exclusion Criteria: 1. Women and men \<50 years 2. Women, pre- or peri-menopausal 3. BMI \<25 and \>35 kg/m2 4. Current smokers or former smoker who quit \< 6 months 5. Use of nicotine replacement products within last 6 months 6. Replacement or gender affirming hormonal therapy use 7. Weight gain of \>15 pounds within last 6 months 8. Infrequent bowel movements 9. History of anemia within past 2 years or confirmation of anemia at first study visit 10. Blood donation within last 2 months 11. Untreated hypertension 12. Oral antibiotics use within 2 weeks of study entry 13. Steroid use (including dental prophylaxis use within 2 wks prior to or during study, except non-prescription topical and nasal steroids, e. g. Flonase) 14. Use of lipid lowering medications 15. Chronic use of aspirin, non-steroidal anti-inflammatory medications (NSAIDS), laxatives, anti-diarrheal medication 16. Regular use (\>2 times per week) of acid lowering medication: antacids, proton pump inhibitors, or H2 Blockers. 17. Use of dietary supplements other than multi-vitamins, including pre- and probiotics, within 2 months of study entry 18. Milk allergy, lactose intolerance or adherence to vegan or other dietary patterns that exclude dairy products 19. Colonoscopy within 3 weeks of study entry or during study period 20. Diagnosis of malabsorption, inflammatory bowel disease (ulcerative colitis or Crohn's Disease), cirrhosis, history of gastrointestinal resection (other than appendectomy), chronic pancreatitis or any other chronic GI disease that in the opinion of the study physician would alter the study results 21. Chronic heart, liver, thyroid, renal or kidney disease 22. Type I or type II diabetes 23. Alcohol consumption \>7 drinks/week for women and \>14 drinks/week for men 24. Inadequate refrigerator storage capacity to store 21 8-oz containers of milk or yogurt 25. Participation in other dietary intervention research study during the same time 26. No social security number 27. Not willing to commit to adhering to the protocol

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Jean Mayer Human Nutrition Research Center on Aging

    Boston, Massachusetts, 02111, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.