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Own hamstring vs. donor tissue: which knee graft wins?

NCT ID NCT07204587

Disease control Sponsor: Chang Gung Memorial Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two surgical options for young adults (18-45) with persistent knee pain after meniscus removal: using a piece of their own hamstring tendon or a donor meniscus. Forty participants will be assigned to one of four groups, including randomized and preference-based choices. The main goal is to see which graft leads to better knee function and pain relief two years after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Autologous semitendinosus tendon graft (a piece of the patient's own hamstring tendon) and meniscal allograft (donor meniscus tissue)
What this could lead to
If successful, this could show that using a patient's own hamstring tendon is a safe and effective alternative to donor tissue for meniscus reconstruction, potentially reducing costs and wait times.
What could go wrong
This is a small, early-stage trial with only 40 participants, so results may not apply to everyone. Both procedures are surgeries with standard risks like infection or graft failure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2025

An estimate. Start dates often move.

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 45 years History of partial meniscectomy \> 6 months prior to enrollment Symptomatic post-meniscectomy syndrome (knee pain, swelling, or functional decline) MRI showing cartilage status ≤ Outerbridge grade 2 Knee joint stability (or stabilized during the index surgery) Body mass index (BMI) \< 30 Willingness to provide written informed consent Exclusion Criteria: Tibial slope \> 16° Radiographic or arthroscopic evidence of advanced cartilage degeneration (Outerbridge \> 2 or ICRS ≥ 3) Presence of inflammatory arthritis or systemic inflammatory joint disease History of cartilage repair surgery Malalignment \> 5° not corrected Untreated ligamentous instability Any other condition judged by the investigator to compromise study participation or outcomes

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Meniscal injuries Meniscal tear Meniscus lesion

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Chang Gung memorial hospital, Taoyuan, taoyuan 333

    Taoyuan City, Taoyuan, 33305, Taiwan

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