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Bone marrow wrap boosts meniscus repair in new study

NCT ID NCT03968029

Disease control Sponsor: Centre Hospitalier Universitaire Vaudois Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding a bone marrow injection under a collagen membrane (meniscal wrapping) helps heal meniscal tears in the non-vascular area better than sutures alone. 96 patients with symptomatic or traumatic meniscal tears were randomly assigned to receive either sutures plus wrapping or sutures only. The researchers tracked healing via imaging and symptom scores over 24 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bone marrow injection with collagen membrane
What this could lead to
If it works, this could improve healing of meniscal tears in the non-vascular area, reducing the need for repeat surgery.
What could go wrong
This is a small, completed trial with no phase designation, so results may not be conclusive or widely applicable. Risks include inflammation, pain, or recurrent tear.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

96 people

The number who actually took part.

Started

Jul 2017

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Symptomatic or traumatic tears of medial or lateral meniscus; * Tearing affecting: only 2/3 central (= avascular zone) over more than 1 cm OR extending from the peripheral third (= vascularized area) within the avascular zone over more than 1 cm. In this case, preservation of the peripheral third over a width of at least 4 mm from the capsule; * Single or multiple tears. Exclusion Criteria: * Meniscal tears that can not be sutured, reduced / approximated * Tear creating a meniscal root avulsion * Partial meniscal tears * Meniscal tears already sutured * Cartilage damage in the compartment\> grade 2 (ICRS classification) * Mechanical axis (varus / valgus) ≥ 2 ° * Untreated ligament deficiency * Osteotomy and / or concomitant ligament reconstruction, with the exception of ACL reconstruction. * Compromised general health condition (score ASA score\> 2) * BMI ≥30 * Active smoking, drug use * Allergy to porcine collagen * Poor compliance

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Meniscus lesion

Contacts and locations

Locations

  • Centre Hospitalier Universitaire Vaudois - CHUV

    Lausanne, Canton of Vaud, 1011, Switzerland

  • Dr Robin MARTIN

    Lausanne, Canton of Vaud, 1011, Switzerland

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