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Brain scans may predict who gets long-term pain from arthritis

NCT ID NCT05038553

Knowledge-focused Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at why some people with early rheumatoid arthritis develop long-lasting chronic pain while others do not. Researchers will use pain sensitivity tests and brain scans to find clues. The goal is to better understand the transition from acute to chronic pain, which could one day lead to better prevention or treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could identify early warning signs and targets to prevent chronic pain in people with rheumatoid arthritis.
What could go wrong
This is an observational study, not a treatment trial. It may not lead to any direct medical changes, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 125 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2021

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with early RA recruited from academic medical centers

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for QST: 1. Age ≥18 years 2. Meet either the 1987 or 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria for RA 3. Persistent joint symptoms ≤ 2 years 4. Active inflammatory disease 5. If taking opioids on an as needed (prn) basis, must be able to hold opioid for 12 hours before study procedures 6. If taking NSAIDs, must be able to hold NSAIDS for 24 hours before study procedures 7. If taking a central-acting pain medication, must be on a stable dose and able to stay on a stable dose throughout study Exclusion Criteria for QST: 1. Routine, scheduled opioid use 2. Routine, scheduled prednisone dose \>10 mg or its equivalent 3. Peripheral neuropathy 4. Peripheral vascular disease 5. Raynaud's phenomenon requiring treatment, manifested by claudication or ischemic rest pain 6. Uncontrolled blood pressure Additional Inclusion Criteria for neuroimaging: 1. Age ≤ 80 years old 2. Right-handed or ambidextrous 3. Ability to lie on their back for the duration of the MRI scans Additional Exclusion Criteria for neuroimaging: 1. Severe claustrophobia precluding MRI 2. Unable to fit comfortably in the MRI scanner (usually only occurs if body mass index \>40 kg/m2) 3. Pregnant 4. Contraindications to MRI

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Conditions

The condition(s) this trial relates to.

Pain rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Arthritis rheumatoid Pain

Contacts and locations

Locations

  • Hospital for Special Surgery

    New York, New York, 10021, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21224, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • University of Colorado

    Denver, Colorado, 80045, United States

  • University of Michigan

    Ann Arbor, Michigan, 48019, United States

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