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Could a new anesthetic keep your mind sharper after a procedure?

NCT ID NCT07673978

Disease control Sponsor: The Second Affiliated Hospital of Chongqing Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This study compares two sedatives—ciprofol and propofol—used during painless gastroscopy and colonoscopy. The goal is to see which drug leads to less cognitive decline after the procedure. Researchers will also monitor side effects like changes in blood pressure and heart rate. The trial includes adults aged 18–65 with normal cognitive function before the procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ciprofol
What this could lead to
If ciprofol causes less cognitive decline than propofol, it could become a preferred anesthetic for procedures like endoscopy, especially in older adults.
What could go wrong
This is a single-center Phase 4 study with 298 participants, so results may not apply broadly. Cognitive changes after anesthesia are often temporary and hard to measure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 298 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age: 18-65 years old, ASA grade I-Ⅲ, BMI index: 18.5-30 kg/m ² 2. Patients who plan to undergo gastroscopy or colonoscopy in our hospital 3. The preoperative assessment of the MOCA scale in patients scheduled for elective surgery indicated normal cognitive function 4. dextromanuality 5. Voluntarily participate in this study and sign the informed consent form Exclusion Criteria: 1. Pregnant or lactating women 2. Patients who have had cardiovascular and cerebrovascular accidents in the past 3. Patients with severe diseases of the cardiovascular system, respiratory system and liver and kidney system 4. Patients with obstructive sleep apnea syndrome 5. Patients with concurrent neurological or mental system diseases, or those with incomplete intellectual development 6. Patients allergic to ciprofol or propofol drugs 7. Patients with braking, visual/auditory impairments 8. Patients with psychotropic drug addiction or alcohol dependence 9. Patients who themselves or their attending physicians refused to participate in the study

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Conditions

The condition(s) this trial relates to.

Postoperative Cognitive Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative cognitive dysfunction

Contacts and locations

Locations

  • The Second Affiliated Hospital Of Chongqing Medical University

    Chongqing, Chongqing Municipality, 400010, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.