Caffeine may clear Post-Surgery brain fog in seniors
NCT ID NCT05574400
First seen Apr 26, 2026 · Last updated Jun 23, 2026 · Updated 14 times
Summary
This study tests whether giving caffeine to adults aged 70 and older after major surgery can lower their risk of postoperative delirium—a state of sudden confusion. Researchers will compare low-dose and high-dose caffeine against a placebo in 250 participants. The goal is to see if a common, safe substance can improve mental recovery.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
-
Michigan Medicine
Ann Arbor, Michigan, 48109, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
caffeine citrate
What this could lead to
If it works, this could point toward a simple, low-cost way to prevent confusion and cognitive decline after major surgery in older adults.
What could go wrong
This is a mid-stage trial with only 250 participants, so results may not apply to everyone. Caffeine can cause side effects like jitters or heart issues, and it might not reduce delirium at all.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.