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Keto diet before bypass surgery may shield seniors from brain fog

NCT ID NCT06480708

Prevention Sponsor: University of Missouri-Columbia Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study planned to test whether a 14-day ketogenic diet before heart bypass surgery could reduce confusion and memory loss in adults aged 60 and older. The diet was thought to lower brain inflammation and improve brain cell health. However, the study was withdrawn before any participants were enrolled, so no results are available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Expected to start

Jan 2026

An estimate. Start dates often move.

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Age ≥ 60 years old * Undergoing elective on-pump coronary artery bypass grafting (CABG) surgery with/without valve repair/replacement. * Mini-Cog score \>4 at baseline. * Negative for delirium on the CAM at baseline. Exclusion criteria (general): * Pre-existing diagnosis of dementia, Alzheimer's Disease, Parkinson's Disease. * Emergent CABG ± valve surgery. * Patients already hospitalized for CABG ± valve surgery. * Patients using GLP-1 agonists. * Inability to provide written, informed consent in English. * Patients who cannot tolerate the KD. * Patients with alcoholism. * Patients with liver failure. * Patients with uremia. * Mini-Cog score \<4 at baseline. * Positive for delirium on the CAM at baseline. Exclusion criteria (MRI/MRS): * Claustrophobia * Patients with any metal in their body. * Patients with pacemakers/internal defibrillators/neurostimulators. * Patients who have any form of stents.

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Conditions

The condition(s) this trial relates to.

Ketosis Neuroinflammatory Diseases Postoperative Cognitive Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative cognitive dysfunction

Contacts and locations

Locations

  • University on Missouri Hospital

    Columbia, Missouri, 65212, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.