Experimental drug cilengitide tested with Chemo-Radiation for lung cancer
NCT ID NCT01118676
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tested the drug cilengitide given continuously along with standard chemotherapy and radiation in 14 patients with locally advanced non-small cell lung cancer. The main goal was to find the highest safe dose of cilengitide when used this way. Researchers also looked at how well the tumors responded and how long patients lived.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- cilengitide
- What this could lead to
- If successful, this could help determine a safe dose of cilengitide combined with standard chemoradiation for advanced lung cancer.
- What could go wrong
- This is a very early, small Phase 1 trial with only 14 patients, so it cannot prove effectiveness. The main goal is safety, not treatment benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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14 people
The number who actually took part.
- Start date
-
Mar 2010
- Finished
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Apr 2015
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Histologically proven non small cell lung cancer 2. Inoperable tage IIIA or IIIB non small cell lung cancer 3. Age ≥ 18 years 4. PerfLife expectancy ≥6 months 5. Hematological function : neutrophils ≥1500/mm3 and platelets ≥ 100000/mm3 6. Hepatic function: Bilirubin within normal limits et AST and ALT ≤ 2 times the upper limit of normal (ULN). 7. Renal function: Creatinine ≤ 1.5 times ULN. 8. Absence of cardiac insufficiency, absence of unstable angina, absence of arrythmia 9. Patient has health insurance coverage. 10. Signed informed consent. Exclusion Criteria: 1. Patients previously treated for a malignancy by means of chemotherapy, radiotherapy or surgery. 2. Uncontrolled hypertension 3. Uncontrolled bleeding within the last 3 months. 4. Patients under anti-coagulation with anti-vitamin K or therapeutic dose heparin ; low-molecular heparins for prophylaxis are permitted and are not considered an exclusion criterion. 5. Presence of cerebral metastases. 6. Participation in a clinical trial within the last 8 weeks. 7. Any other specific concomitant anti-tumor treatment (such as chemotherapy, radiotherapy …). 8. Patients with a history of myocardial infarction or a cerebral vascular accident within the last 12 months. 9. Continued use of aspirin (\>325mg/day) 10. Major surgery whiting the last 28 days or planned. 11. Major non-healing wound, ulcer 12. Pregnant or breastfeeding women cannot participate in this trial. Women of reproductive potential must have a negative pregnancy test (blood) within 72 hours before the start of treatment. 13. Men and women of reproductive potential must use an efficient contraceptive method when entering the trial and until one months after the end of treatment. 14. History of a thrombo-embolic or hemorrhagic event. 15. Patients put under tutelage. 16. Patients not able to follow the procedures visits, exams foreseen by the trial. 17. Any other severe medical or psychiatric condition or biological anomaly - acute or chronic - that, in the investigator's opinion - may render the inclusion of the patient inappropriate.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU Toulouse Larrey
Toulouse, 31000, France
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Institut Claudius Regaud
Toulouse, 31000, France
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