Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Experimental drug cilengitide tested with Chemo-Radiation for lung cancer

NCT ID NCT01118676

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial tested the drug cilengitide given continuously along with standard chemotherapy and radiation in 14 patients with locally advanced non-small cell lung cancer. The main goal was to find the highest safe dose of cilengitide when used this way. Researchers also looked at how well the tumors responded and how long patients lived.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cilengitide
What this could lead to
If successful, this could help determine a safe dose of cilengitide combined with standard chemoradiation for advanced lung cancer.
What could go wrong
This is a very early, small Phase 1 trial with only 14 patients, so it cannot prove effectiveness. The main goal is safety, not treatment benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

14 people

The number who actually took part.

Start date

Mar 2010

Finished

Apr 2015

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Histologically proven non small cell lung cancer 2. Inoperable tage IIIA or IIIB non small cell lung cancer 3. Age ≥ 18 years 4. PerfLife expectancy ≥6 months 5. Hematological function : neutrophils ≥1500/mm3 and platelets ≥ 100000/mm3 6. Hepatic function: Bilirubin within normal limits et AST and ALT ≤ 2 times the upper limit of normal (ULN). 7. Renal function: Creatinine ≤ 1.5 times ULN. 8. Absence of cardiac insufficiency, absence of unstable angina, absence of arrythmia 9. Patient has health insurance coverage. 10. Signed informed consent. Exclusion Criteria: 1. Patients previously treated for a malignancy by means of chemotherapy, radiotherapy or surgery. 2. Uncontrolled hypertension 3. Uncontrolled bleeding within the last 3 months. 4. Patients under anti-coagulation with anti-vitamin K or therapeutic dose heparin ; low-molecular heparins for prophylaxis are permitted and are not considered an exclusion criterion. 5. Presence of cerebral metastases. 6. Participation in a clinical trial within the last 8 weeks. 7. Any other specific concomitant anti-tumor treatment (such as chemotherapy, radiotherapy …). 8. Patients with a history of myocardial infarction or a cerebral vascular accident within the last 12 months. 9. Continued use of aspirin (\>325mg/day) 10. Major surgery whiting the last 28 days or planned. 11. Major non-healing wound, ulcer 12. Pregnant or breastfeeding women cannot participate in this trial. Women of reproductive potential must have a negative pregnancy test (blood) within 72 hours before the start of treatment. 13. Men and women of reproductive potential must use an efficient contraceptive method when entering the trial and until one months after the end of treatment. 14. History of a thrombo-embolic or hemorrhagic event. 15. Patients put under tutelage. 16. Patients not able to follow the procedures visits, exams foreseen by the trial. 17. Any other severe medical or psychiatric condition or biological anomaly - acute or chronic - that, in the investigator's opinion - may render the inclusion of the patient inappropriate.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Locally advanced non-small cell lung cancer (NSCLC) are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CHU Toulouse Larrey

    Toulouse, 31000, France

  • Institut Claudius Regaud

    Toulouse, 31000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.