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Two-Drug cocktail aims to boost chemo against tough lung cancer

NCT ID NCT07680764

Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 02, 2026 · Last updated Sep 17, 2026 · Updated 3 times

Summary

This phase 2 trial tests whether adding two experimental drugs, imzokitug and pumitamig, to standard chemotherapy helps people with advanced non-small cell lung cancer (NSCLC) who have not had prior treatment. About 160 participants will receive either the three-drug combination or pumitamig plus chemo alone. The main goal is to see if the combination shrinks tumors more effectively, while also monitoring side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
imzokitug and pumitamig
What this could lead to
If successful, this combination could offer a more effective first-line treatment for advanced non-small cell lung cancer, potentially shrinking tumors and delaying progression.
What could go wrong
This is an early-phase trial with a small number of participants. The added drug may increase side effects without improving outcomes, and results may not apply to all lung cancer types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 160 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Sep 2030

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Participants must have histologically confirmed diagnosis of stage IV non-small cell lung cancer (NSCLC) (squamous or non-squamous) or recurrent unresectable disease per the American joint committee on cancer (AJCC) Staging System 9th edition. * Participants must have no prior systemic anti-cancer therapy given as primary therapy for advanced or metastatic disease. * Tumor tissue (fresh or archival) obtained within 5 months of enrollment (signing of informed consent) for each participant must be submitted by the site. * Participants must have an Eastern Cooperative Oncology Group Performance Status of 0 or 1. * Participants must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. Exclusion Criteria * Participants must not have any documented actionable genomic alterations (AGAs) for which first line approved targeted therapies are indicated. * Participants must not have prior treatment with immuno-oncology therapies. * Participants must not have untreated central nervous system (CNS) metastases. * Other protocol-defined Inclusion/Exclusion criteria apply.

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Locally advanced non-small cell lung cancer (NSCLC) Metastatic non-small cell lung cancer (NSCLC)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    70 sites in 12 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Local Institution - 0001

    NOT_YET_RECRUITING

    São Paulo, 01246-000, Brazil

  • Local Institution - 0003

    NOT_YET_RECRUITING

    Natal/RN, Rio Grande do Norte, 59062-000, Brazil

  • Local Institution - 0005

    NOT_YET_RECRUITING

    Barretos, São Paulo, 14784, Brazil

  • Local Institution - 0006

    NOT_YET_RECRUITING

    Porto Alegre, Rio Grande do Sul, 91610-000, Brazil

  • Local Institution - 0008

    NOT_YET_RECRUITING

    Cluj-Napoca, 400015, Romania

  • Local Institution - 0010

    NOT_YET_RECRUITING

    Majadahonda, 28222, Spain

  • Local Institution - 0011

    NOT_YET_RECRUITING

    Rozzano (MI), 20089, Italy

  • Local Institution - 0014

    NOT_YET_RECRUITING

    Ravenna, 48121, Italy

  • Local Institution - 0019

    NOT_YET_RECRUITING

    Paris, Île-de-France Region, 75005, France

  • Local Institution - 0020

    NOT_YET_RECRUITING

    Málaga, 29010, Spain

  • Local Institution - 0027

    NOT_YET_RECRUITING

    Barcelona, 08035, Spain

  • Local Institution - 0034

    NOT_YET_RECRUITING

    Lexington, Kentucky, 40503, United States

  • Local Institution - 0035

    NOT_YET_RECRUITING

    London, Greater London, SE19RT, United Kingdom

  • Local Institution - 0037

    NOT_YET_RECRUITING

    Guildford, GU2 7XX, United Kingdom

  • Local Institution - 0038

    NOT_YET_RECRUITING

    Beijing, Beijing Municipality, 100142, China

  • Local Institution - 0041

    WITHDRAWN

    Madrid, 28041, Spain

  • Local Institution - 0042

    NOT_YET_RECRUITING

    Haile, 06120, Germany

  • Local Institution - 0043

    NOT_YET_RECRUITING

    Bari, 70124, Italy

  • Local Institution - 0047

    NOT_YET_RECRUITING

    Grenoble, 38043 Cedex 09, France

  • Local Institution - 0048

    NOT_YET_RECRUITING

    Perth, Western Australia, 6150, Australia

  • Local Institution - 0050

    NOT_YET_RECRUITING

    Wuhan, Hubei, 430030, China

  • Local Institution - 0065

    NOT_YET_RECRUITING

    Cologne, 51109, Germany

  • Local Institution - 0068

    NOT_YET_RECRUITING

    Barcelona, 08041, Spain

  • Local Institution - 0074

    NOT_YET_RECRUITING

    Gosford, New South Wales, 2250, Australia

  • Local Institution - 0075

    NOT_YET_RECRUITING

    Craiova, 200347, Romania

  • Local Institution - 0076

    NOT_YET_RECRUITING

    Bucharest, 022328, Romania

  • Local Institution - 0080

    NOT_YET_RECRUITING

    New York, New York, 10021, United States

  • Local Institution - 0081

    NOT_YET_RECRUITING

    Santiago, Santiago Metropolitan, 7500713, Chile

  • Local Institution - 0082

    NOT_YET_RECRUITING

    Rosario, Santa Fe Province, 2000, Argentina

  • Local Institution - 0084

    NOT_YET_RECRUITING

    Viña del Mar, Valparaiso, 2520598, Chile

  • Local Institution - 0085

    NOT_YET_RECRUITING

    Saint-Herblain, 44800, France

  • Local Institution - 0087

    NOT_YET_RECRUITING

    Montpellier, Languedoc-Roussillon, 34070, France

  • Local Institution - 0092

    NOT_YET_RECRUITING

    Viedma, R8500ACE, Argentina

  • Local Institution - 0094

    NOT_YET_RECRUITING

    Buenos Aires, C1426ANZ, Argentina

  • Local Institution - 0095

    NOT_YET_RECRUITING

    Houston, Texas, 77030, United States

  • Local Institution - 0100

    NOT_YET_RECRUITING

    Heidelberg, Victoria, 3084, Australia

  • Local Institution - 0109

    NOT_YET_RECRUITING

    Paris, 75014, France

  • Local Institution - 0110

    NOT_YET_RECRUITING

    Marseille, Bouches-du-Rhône, 13385, France

  • Local Institution - 0113

    NOT_YET_RECRUITING

    Timișoara, Timiș County, 300239, Romania

  • Local Institution - 0114

    NOT_YET_RECRUITING

    Florești, Cluj, 407280, Romania

  • Local Institution - 0115

    NOT_YET_RECRUITING

    Iași, 700106, Romania

  • Local Institution - 0116

    NOT_YET_RECRUITING

    Iași, 700483, Romania

  • Local Institution - 0119

    NOT_YET_RECRUITING

    Villejuif, Val-de-Marne, 94800, France

  • Local Institution - 0123

    NOT_YET_RECRUITING

    Baltimore, Maryland, 21224, United States

  • Local Institution - 0125

    NOT_YET_RECRUITING

    Hessen, 60590, Germany

  • Local Institution - 0126

    NOT_YET_RECRUITING

    Stuttgart, Baden-Wurttemberg, 70376, Germany

  • Local Institution - 0128

    NOT_YET_RECRUITING

    Misterbianco, Catania, 95045, Italy

  • Local Institution - 0131

    NOT_YET_RECRUITING

    Nice, Alpes-Maritimes, 6100, France

  • Local Institution - 0132

    NOT_YET_RECRUITING

    Badalona, Barcelona, 8916, Spain

  • Local Institution - 0134

    NOT_YET_RECRUITING

    Westmead, New South Wales, 2145, Australia

  • Local Institution - 0135

    NOT_YET_RECRUITING

    Madison, Wisconsin, 53792, United States

  • Local Institution - 0137

    NOT_YET_RECRUITING

    Hangzhou, Zhejiang, 310016, China

  • Local Institution - 0138

    NOT_YET_RECRUITING

    Fuzhou, Fujian, 350014, China

  • Local Institution - 0140

    NOT_YET_RECRUITING

    Shanghai, Shanghai Municipality, 200030, China

  • Local Institution - 0144

    NOT_YET_RECRUITING

    Chengdu, Sichuan, 610213, China

  • Local Institution - 0147

    NOT_YET_RECRUITING

    Nanjing, Jiangsu, 210029, China

  • Local Institution - 0148

    NOT_YET_RECRUITING

    Bergamo, 24128, Italy

  • Local Institution - 0149

    NOT_YET_RECRUITING

    Santiago, Santiago Metropolitan, 8420383, Chile

  • Local Institution - 0152

    NOT_YET_RECRUITING

    Homburg, Saarland, 66424, Germany

  • Local Institution - 0156

    NOT_YET_RECRUITING

    Marburg, Hesse, 35043, Germany

  • Local Institution - 0159

    NOT_YET_RECRUITING

    Milan, 20142, Italy

  • Local Institution - 0162

    NOT_YET_RECRUITING

    Seville, Seville, 41013, Spain

  • Local Institution - 0163

    NOT_YET_RECRUITING

    Barcelona, 8036, Spain

  • Local Institution - 0167

    NOT_YET_RECRUITING

    Greenslopes, Queensland, 4120, Australia

  • Local Institution - 0169

    NOT_YET_RECRUITING

    Shanghai, Shanghai Municipality, 200032, China

  • Local Institution - 0170

    NOT_YET_RECRUITING

    Athens, Georgia, 30607, United States

  • Local Institution - 0171

    NOT_YET_RECRUITING

    Lexington, Kentucky, 40509, United States

  • Local Institution - 0180

    NOT_YET_RECRUITING

    Hattiesburg, Mississippi, 39401, United States

  • Local Institution - 0182

    NOT_YET_RECRUITING

    Birmingham, West Midlands, B95SS, United Kingdom

  • Nebraska Cancer Specialists

    RECRUITING

    Grand Island, Nebraska, 68803, United States

  • Oncology Hematology West PC

    RECRUITING

    Omaha, Nebraska, 68130, United States

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