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Bilingual brain boost: new therapy targets language loss in dementia

NCT ID NCT05741853

Symptom relief Sponsor: Stephanie Grasso Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a speech therapy program for bilingual Spanish-English or Spanish-Catalan speakers with primary progressive aphasia, a condition that slowly damages language abilities. Sixty participants will receive personalized script training via video sessions, while 30 others will only undergo testing. The goal is to see if therapy improves speech and quality of life, and how bilingualism affects recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Video-Implemented Script Training for Aphasia (VISTA) - a behavioral speech therapy
What this could lead to
If successful, this could provide an effective, tailored speech therapy for bilingual individuals with primary progressive aphasia, improving their communication and daily life.
What could go wrong
This is an early-stage trial with only 60 participants, so results may not apply to all bilinguals. The therapy may not work for everyone, and benefits might be modest or temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2023

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011) * Bilingual in Spanish and Catalan or bilingual in Spanish and English * Different proficiency levels across languages are expected, any prior experience in both languages is acceptable * Intervention study: Score of 15 or higher on the Mini-Mental State Examination * Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of 10 or higher on the Mini-Mental State Examination Exclusion Criteria: * Other central nervous system or medical diagnosis that can cause symptoms * Other psychiatric diagnosis that can cause symptoms * Significant, uncorrected visual or hearing impairment that would interfere with participation * Prominent initial non-speech-language impairments (cognitive, behavioral, motoric) * Intervention Study: Score of less than 15 on the Mini-Mental State Examination * Note that this project will also recruit individuals to participate in assessment only, for these individuals the following inclusion criteria applies: Score of less than 10 on the Mini-Mental State Examination

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Conditions

The condition(s) this trial relates to.

Alzheimer disease aphasia apraxia cognitive disorder communication disorder dementia Dysarthria frontotemporal dementia Frontotemporal Lobar Degeneration language disorder neurodegenerative disease primary progressive aphasia semantic dementia speech disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer disease Aphasia Apraxia, motor Bilingual aphasia Communication disorders Dementia Dementia, frontotemporal Dysarthria Frontotemporal lobar degeneration Language disorders Neurocognitive disorders Neurodegenerative diseases Primary progressive aphasia Speech disorders

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital Clínic de Barcelona

    NOT_YET_RECRUITING

    Barcelona, 08036, Spain

  • Hospital de la Santa Creu i Sant Pau

    RECRUITING

    Barcelona, Barcelona, 08025, Spain

  • University of Texas at Austin

    RECRUITING

    Austin, Texas, 78752, United States

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