Could an extra antibody slow HER2+ breast cancer spread?

NCT ID NCT00520975

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial investigates whether adding bevacizumab (Avastin) to standard first-line chemotherapy plus trastuzumab (Herceptin) helps people with HER2-positive metastatic breast cancer. Participants receive either bevacizumab or a placebo alongside their regular treatment. The main goal is to see if the combination delays cancer progression.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Bevacizumab (Avastin)
What this could lead to: If it works, adding bevacizumab could help people with HER2+ metastatic breast cancer live longer without their disease getting worse.
What could go wrong: This is a phase 3 trial, but results may not show a meaningful benefit. Bevacizumab can cause serious side effects like high blood pressure, bleeding, or blood clots.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

96 people

The number who actually took part.

Start date

Nov 2007

Finished

Oct 2015

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histologically confirmed breast cancer that overexpresses HER-2/NEU with evidence of metastatic disease and/or chest wall recurrence prior to randomization * HER-2/NEU overexpression is defined as 3+ HER-2 positivity as measured by immunohistochemistry OR HER-2 gene amplification as measured by fluorescent in situ hybridization (FISH, e.g. Vysis), per American Society of Clinical Oncology guidelines * NOTE: representative diagnostic tissue must be submitted for central diagnostic review for confirmation of HER-2/NEU overexpression within two weeks following patient randomization * Evaluable (measurable or non-measurable) disease is allowed if confirmed within 4 weeks prior to randomization * Prior endocrine treatment in the adjuvant or metastatic setting is allowed, provided last dose given \>= 2 weeks prior to randomization * Radiation therapy is allowed provided last dose is given \>= 3 weeks prior to randomization * Adjuvant trastuzumab therapy for breast cancer is allowed provided last dose was given \>= 12 months prior to diagnosis of recurrence * Adjuvant or neoadjuvant taxane therapy for breast cancer is allowed provided last dose was given \>= 12 months prior to diagnosis of recurrence * Adjuvant or neoadjuvant therapy with lapatinib is allowed provided last dose is given \>= 4 weeks prior to diagnosis of recurrence * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 * Absolute neutrophil count \>= 1,000/mm\^3 * Platelet count \>= 100,000/mm\^3 * Total bilirubin =\< 1.5 mg/dL * Aspartate aminotransferase (AST) =\< 2 times upper limit of normal (ULN) (=\< 5 times normal in patients with known liver involvement) * Serum creatinine =\< 1.5 mg/dL * Urine protein: creatinine ratio =\< 0.5 OR 24-hour urine protein \< 1000 mg * International normalized ratio (INR) =\< 1.5 X ULN * Partial thromboplastin time (PTT) =\< 1.5 X ULN * Multi gated acquisition scan (MUGA) scan or echocardiogram (ECHO) within 6 weeks prior to randomization with an left ventricular ejection fraction (LVEF) above the institutional lower limit of normal * Patients must be able to understand and provide signed and dated written informed consent * Major surgical procedure within 4 weeks prior to randomization is not allowed (except for non-operative biopsy, which would not be considered major surgery); treatment can not begin until seven (7) days after placement of a vascular access device * Women must not be pregnant or breastfeeding; all females of childbearing potential must have a blood or urine test within 2 weeks prior to randomization to rule out pregnancy; women of childbearing potential and sexually active males must use an accepted and effective method of contraception * Patients on full-dose anticoagulants (e.g., warfarin) with PT/INR \> 1.5 may be eligible provided that both of the following criteria are met: * The patient has an in-range INR (usually between 2 and 3) on a stable dose of oral anticoagulant or on a stable dose of low molecular weight heparin * The patient has not active bleeding or pathological condition that carries a high risk of bleeding (e.g., tumor involving major vessels or known varices) * Patients with a concurrent active malignancy except carcinoma in situ of the cervix or non-melanoma skin cancers (unless disease-free for at least 5 years at study entry) are not allowed Exclusion Criteria: * Prior chemotherapy, trastuzumab, or bevacizumab for metastatic breast cancer * Patients who have had a cumulative dose of doxorubicin of greater than 360 mg/m\^2 or epirubicin of greater than 640 mg/m\^2 in the adjuvant or neo-adjuvant setting at any time * Patients with grade 2-4 neuropathy * Patients with a history or radiologic evidence of central nervous system (CNS) disease * Patients have a current non-healing wound or fracture * Patients have a hypersensitivity to paclitaxel or drugs using the vehicle Cremophor, Chinese hamster ovary cell products or other recombinant human antibodies * Patients have a serious medical or psychiatric illness that would prevent ability to safely participate or provide informed consent * Patients using any of the following drugs known to inhibit platelet function are not eligible: dipyridamole (Persantine), ticlopidine (Ticlid), clopidogrel (Plavix) and cilostazol (Pletal) * Clinically significant cardiovascular disease, including: * History of cerebrovascular (CVA) within 6 months * Uncontrolled hypertension * Myocardial infarction or unstable angina within 6 months * New York Heart Association class II or greater congestive heart failure, serious cardiac arrhythmia requiring medication, unstable angina pectoris * Clinically significant peripheral vascular disease

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm HER2 positive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breast carcinoma Recurrent breast carcinoma Stage IV breast cancer

Contacts and locations

Locations

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States
Adventist Medical Center

Portland, Oregon, 97216, United States
Albert Einstein College of Medicine

The Bronx, New York, 10461, United States
Allegiance Health

Jackson, Michigan, 49201, United States
Alta Bates Summit Medical Center - Summit Campus

Oakland, California, 94609, United States
Aspirus UW Cancer Center

Wisconsin Rapids, Wisconsin, 54494, United States
Associates In Womens Health

Wichita, Kansas, 67208, United States
Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States
Avera Saint Luke's Hospital and Cancer Center

Aberdeen, South Dakota, 57401, United States
Baton Rouge General Medical Center

Baton Rouge, Louisiana, 70806, United States
Bay Area Breast Surgeons Inc

Emeryville, California, 94608, United States
Bay Area Medical Center

Marinette, Wisconsin, 54143, United States
Bay Area Tumor Institute

Oakland, California, 94609, United States
Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Berdeaux, Donald MD (UIA Investigator)

Great Falls, Montana, 59405, United States
Billings Clinic Cancer Center

Billings, Montana, 59107, United States
Bixby Medical Center

Adrian, Michigan, 49221, United States
Blanchard Valley Hospital

Findlay, Ohio, 45840, United States
Boulder Community Hospital

Boulder, Colorado, 80301, United States
Bozeman Deaconess Cancer Center

Bozeman, Montana, 59715, United States
Bozeman Deaconess Hospital

Bozeman, Montana, 59715, United States
Bromenn Regional Medical Center

Normal, Illinois, 61761, United States
CHI Health Good Samaritan

Kearney, Nebraska, 68847, United States
Camden-Clark Memorial Hospital

Parkersburg, West Virginia, 26101, United States
Cancer Care Associates

Oklahoma City, Oklahoma, 73120, United States
Cancer Care Northwest - Spokane South

Spokane, Washington, 99202, United States
Cancer Center of Kansas - Chanute

Chanute, Kansas, 66720, United States
Cancer Center of Kansas - Dodge City

Dodge City, Kansas, 67801, United States
Cancer Center of Kansas - El Dorado

El Dorado, Kansas, 67042, United States
Cancer Center of Kansas - Fort Scott

Fort Scott, Kansas, 66701, United States
Cancer Center of Kansas - Main Office

Wichita, Kansas, 67214, United States
Cancer Center of Kansas - Newton

Newton, Kansas, 67114, United States
Cancer Center of Kansas - Parsons

Parsons, Kansas, 67357, United States
Cancer Center of Kansas - Pratt

Pratt, Kansas, 67124, United States
Cancer Center of Kansas - Salina

Salina, Kansas, 67401, United States
Cancer Center of Kansas - Wellington

Wellington, Kansas, 67152, United States
Cancer Center of Kansas - Winfield

Winfield, Kansas, 67156, United States
Cancer Center of Kansas-Independence

Independence, Kansas, 67301, United States
Cancer Center of Kansas-Kingman

Kingman, Kansas, 67068, United States
Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas, 67208, United States
Cancer Research for the Ozarks NCORP

Springfield, Missouri, 65804, United States
Cape Fear Valley Health System

Fayetteville, North Carolina, 28304, United States
Capital Regional Medical Center

Jefferson City, Missouri, 65101, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carle Clinic-Urbana Main

Urbana, Illinois, 61801, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Center for Cancer Care and Research

St Louis, Missouri, 63141, United States
Clements University Hospital

Dallas, Texas, 75390, United States
Clinton Memorial Hospital

Wilmington, Ohio, 45177, United States
Colorado Cancer Research Program NCORP

Denver, Colorado, 80222, United States
Columbus NCI Community Oncology Research Program

Columbus, Ohio, 43215, United States
Community Cancer Center Foundation

Normal, Illinois, 61761, United States
Community Hospital of Monterey Peninsula

Monterey, California, 93940, United States
Community Howard Regional Health

Kokomo, Indiana, 46904, United States
Community Medical Hospital

Missoula, Montana, 59801, United States
Constantinou, Costas L MD (UIA Investigator)

Bettendorf, Iowa, 52722, United States
Contra Costa Regional Medical Center

Martinez, California, 94553-3156, United States
Covenant Medical Center

Waterloo, Iowa, 50702, United States
Danville Regional Medical Center

Danville, Virginia, 24541, United States
Dayton NCI Community Oncology Research Program

Dayton, Ohio, 45420, United States
Dean Hematology and Oncology Clinic

Madison, Wisconsin, 53717, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Diagnostic and Treatment Center

Weston, Wisconsin, 54476, United States
Doctors Hospital

Columbus, Ohio, 43228, United States
Doctors Medical Center- JC Robinson Regional Cancer Center

San Pablo, California, 94806, United States
Doylestown Hospital

Doylestown, Pennsylvania, 18901, United States
DuPage Medical Group-Ogden

Naperville, Illinois, 60563, United States
East Bay Radiation Oncology Center

Castro Valley, California, 94546, United States
Eastern Connecticut Hematology and Oncology Associates

Norwich, Connecticut, 06360, United States
Eastern Maine Medical Center

Bangor, Maine, 04401, United States
Eden Hospital Medical Center

Castro Valley, California, 94546, United States
Edward Hospital/Cancer Center

Naperville, Illinois, 60540, United States
El Camino Hospital

Mountain View, California, 94040, United States
Elkhart General Hospital

Elkhart, Indiana, 46515, United States
Emory University/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Erlanger Medical Center

Chattanooga, Tennessee, 37403, United States
Essentia Health Cancer Center

Duluth, Minnesota, 55805, United States
Essentia Health Saint Mary's Medical Center

Duluth, Minnesota, 55805, United States
Eureka Hospital

Eureka, Illinois, 61530, United States
Exempla Saint Joseph Hospital

Denver, Colorado, 80218, United States
Fairfield Medical Center

Lancaster, Ohio, 43130, United States
Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States
Fairview-Southdale Hospital

Edina, Minnesota, 55435, United States
Flower Hospital

Sylvania, Ohio, 43560, United States
Franciscan Saint Anthony Health-Michigan City

Michigan City, Indiana, 46360, United States
Franciscan St. Francis Health-Beech Grove

Beech Grove, Indiana, 46107, United States
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
Fredericksburg Oncology Inc

Fredericksburg, Virginia, 22401, United States
Fremont - Rideout Cancer Center

Marysville, California, 95901, United States
Frontier Cancer Center and Blood Institute-Billings

Billings, Montana, 59102, United States
Fulton County Health Center

Wauseon, Ohio, 43567, United States
Galesburg Cottage Hospital

Galesburg, Illinois, 61401, United States
Garneau, Stewart C MD (UIA Investigator)

Moline, Illinois, 61265, United States
Gaston Memorial Hospital

Gastonia, North Carolina, 28054, United States
Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701, United States
Genesis Medical Center - East Campus

Davenport, Iowa, 52803, United States
Genesis Medical Center - West Campus

Davenport, Iowa, 52804, United States
Genesys Regional Medical Center-West Flint Campus

Flint, Michigan, 48532, United States
Glacier Oncology PLLC

Kalispell, Montana, 59901, United States
Good Samaritan Hospital - Dayton

Dayton, Ohio, 45406, United States
Grady Health System

Atlanta, Georgia, 30303, United States
Grady Memorial Hospital

Delaware, Ohio, 43015, United States
Graham Hospital Association

Canton, Illinois, 61520, United States
Grand View Hospital

Sellersville, Pennsylvania, 18960, United States
Grandview Hospital

Dayton, Ohio, 45405, United States
Grant Medical Center

Columbus, Ohio, 43215, United States
Great Falls Clinic

Great Falls, Montana, 59405, United States
Greater Baltimore Medical Center

Baltimore, Maryland, 21204, United States
Green Bay Oncology - Escanaba

Escanaba, Michigan, 49431, United States
Green Bay Oncology - Iron Mountain

Iron Mountain, Michigan, 49801, United States
Green Bay Oncology - Oconto Falls

Oconto Falls, Wisconsin, 54154, United States
Green Bay Oncology - Sturgeon Bay

Sturgeon Bay, Wisconsin, 54235, United States
Green Bay Oncology Limited at Saint Mary's Hospital

Green Bay, Wisconsin, 54303, United States
Green Bay Oncology at Saint Vincent Hospital

Green Bay, Wisconsin, 54301-3526, United States
Greene Memorial Hospital

Xenia, Ohio, 45385, United States
Group Health Cooperative-Seattle

Seattle, Washington, 98112, United States
Guardian Oncology and Center for Wellness

Missoula, Montana, 59804, United States
Harborview Medical Center

Seattle, Washington, 98104, United States
Harrison HealthPartners Hematology and Oncology-Bremerton

Bremerton, Washington, 98310, United States
Heartland Cancer Research NCORP

Decatur, Illinois, 62526, United States
Hematology Oncology Associates of Illinois - Skokie

Skokie, Illinois, 60076, United States
Hematology Oncology Associates of Illinois-Highland Park

Highland Park, Illinois, 60035, United States
Hematology Oncology Center Incorporated

Elyria, Ohio, 44035, United States
Hematology and Oncology Associates

Chicago, Illinois, 60611, United States
Hematology and Oncology Associates of Rhode Island Inc

Cranston, Rhode Island, 02920, United States
Hematology and Oncology Associates-Oakland

Oakland, California, 94609, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Hickman Cancer Center

Adrian, Michigan, 49221, United States
Highland General Hospital

Oakland, California, 94602, United States
Hinsdale Hematology Oncology Associates Incorporated

Hinsdale, Illinois, 60521, United States
Holy Family Medical Center

Monmouth, Illinois, 61462, United States
Hopedale Medical Complex - Hospital

Hopedale, Illinois, 61747, United States
Hospital District Sixth of Harper County

Anthony, Kansas, 67003, United States
Hurley Medical Center

Flint, Michigan, 48502, United States
Hutchinson Area Health Care

Hutchinson, Minnesota, 55350, United States
IU Health Arnett Cancer Care

Lafayette, Indiana, 47904, United States
IU Health La Porte Hospital

La Porte, Indiana, 46350, United States
Illinois Cancer Specialists-Niles

Niles, Illinois, 60714, United States
Illinois CancerCare Galesburg

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States
Illinois CancerCare-Community Cancer Center

Normal, Illinois, 61761, United States
Illinois CancerCare-Cottage

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States
Illinois CancerCare-Havana

Havana, Illinois, 62644, United States
Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States
Illinois CancerCare-Monmouth

Monmouth, Illinois, 61462, United States
Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States
Illinois CancerCare-Spring Valley

Spring Valley, Illinois, 61362, United States
Illinois Valley Hospital

Peru, Illinois, 61354, United States
Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States
Ingalls Memorial Hospital

Harvey, Illinois, 60426, United States
Inspira Medical Center Vineland

Vineland, New Jersey, 08360, United States
Interim LSU Public Hospital

New Orleans, Louisiana, 70112, United States
Interlakes Foundation Inc-Rochester

Rochester, New York, 14623, United States
Iowa Lutheran Hospital

Des Moines, Iowa, 50316, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
Iowa-Wide Oncology Research Coalition NCORP

Des Moines, Iowa, 50309, United States
John H Stroger Jr Hospital of Cook County

Chicago, Illinois, 60612-3785, United States
Joliet Oncology-Hematology Associates Limited

Joliet, Illinois, 60435, United States
Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States
Kalispell Medical Oncology

Kalispell, Montana, 59901, United States
Kalispell Regional Medical Center

Kalispell, Montana, 59901, United States
Kent County Hospital

Warwick, Rhode Island, 02886, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
Lakeland Hospital

Saint Joseph, Michigan, 49085, United States
Lancaster General Hospital

Lancaster, Pennsylvania, 17604, United States
Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409, United States
Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States
Licking Memorial Hospital

Newark, Ohio, 43055, United States
Lima Memorial Hospital

Lima, Ohio, 45804, United States
Longmont United Hospital

Longmont, Colorado, 80501, United States
Louisiana State University Health Science Center

New Orleans, Louisiana, 70112, United States
MacNeal Hospital and Cancer Center

Berwyn, Illinois, 60402, United States
Margaret R Pardee Memorial Hospital

Hendersonville, North Carolina, 28791, United States
Marietta Memorial Hospital

Marietta, Ohio, 45750, United States
Marshfield Clinic - Wisconsin Rapids Center

Wisconsin Rapids, Wisconsin, 54494, United States
Marshfield Clinic Cancer Center at Sacred Heart

Eau Claire, Wisconsin, 54701, United States
Marshfield Clinic at James Beck Cancer Center

Rhinelander, Wisconsin, 54501, United States
Marshfield Clinic-Rice Lake Center

Rice Lake, Wisconsin, 54868, United States
Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, 70809, United States
Mary Rutan Hospital

Bellefontaine, Ohio, 43311, United States
Mason District Hospital

Havana, Illinois, 62644, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
McFarland Clinic PC-William R Bliss Cancer Center

Ames, Iowa, 50010, United States
McKee Medical Center

Loveland, Colorado, 80539, United States
Mcdonough District Hospital

Macomb, Illinois, 61455, United States
Medical Oncology and Hematology Associates-Des Moines

Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates-Laurel

Des Moines, Iowa, 50314, United States
Meeker County Memorial Hospital

Litchfield, Minnesota, 55355, United States
Memorial Hospital

Carthage, Illinois, 62321, United States
Memorial Hospital at Easton - Shore Regional Cancer Center

Easton, Maryland, 21601, United States
Memorial Hospital of South Bend

South Bend, Indiana, 46601, United States
Memorial Medical Center

Springfield, Illinois, 62781, United States
Memorial University Medical Center

Savannah, Georgia, 31404, United States
Mercy Capitol

Des Moines, Iowa, 50307, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Mercy Hospital of Tiffin

Tiffin, Ohio, 44883, United States
Mercy Hospital-Joplin

Joplin, Missouri, 64804, United States
Mercy Medical Center

Canton, Ohio, 44708, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Mercy Medical Center-Sioux City

Sioux City, Iowa, 51104, United States
Mercy Memorial Hospital

Monroe, Michigan, 48162, United States
Mercy Saint Anne Hospital

Toledo, Ohio, 43623, United States
Methodist Medical Center of Illinois

Peoria, Illinois, 61603, United States
Metro Minnesota Community Oncology Research Consortium

Saint Louis Park, Minnesota, 55416, United States
Miami Valley Hospital

Dayton, Ohio, 45409, United States
Michigan Cancer Research Consortium CCOP

Ann Arbor, Michigan, 48106, United States
Mid Dakota Clinic

Bismarck, North Dakota, 58501, United States
Midwest Center for Hematology Oncology

Joliet, Illinois, 60432, United States
Miller-Dwan Hospital

Duluth, Minnesota, 55805, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology and Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Minor and James Medical PLLC

Seattle, Washington, 98104, United States
Mission Hospital-Memorial Campus

Asheville, North Carolina, 28801, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Montana Cancer Consortium NCORP

Billings, Montana, 59101, United States
Montana Cancer Specialists

Missoula, Montana, 59802, United States
Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467-2490, United States
Morristown Medical Center

Morristown, New Jersey, 07960, United States
Mount Carmel Health Center West

Columbus, Ohio, 43222, United States
NEA Baptist Memorial Hospital

Jonesboro, Arkansas, 72401, United States
North Coast Cancer Care

Sandusky, Ohio, 44870, United States
North Coast Cancer Care-Clyde

Clyde, Ohio, 43410, United States
North Colorado Medical Center

Greeley, Colorado, 80631, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
North Suburban Medical Center

Thornton, Colorado, 80229, United States
NorthShore Hematology Oncology-Libertyville

Libertyville, Illinois, 60048, United States
NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201, United States
Northern Indiana Cancer Research Consortium CCOP

South Bend, Indiana, 46628, United States
Northern Montana Hospital

Havre, Montana, 59501, United States
Northern Rockies Radiation Oncology Center

Billings, Montana, 59101, United States
Northwestern University

Chicago, Illinois, 60611, United States
OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States
Oakwood Hospital and Medical Center

Dearborn, Michigan, 48124, United States
Orange Regional Medical Center

Middletown, New York, 10940, United States
Ottawa Regional Hospital and Healthcare Center

Ottawa, Illinois, 61350, United States
Overlook Hospital

Summit, New Jersey, 07902, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
Pekin Cancer Treatment Center

Pekin, Illinois, 61554, United States
Pekin Hospital

Pekin, Illinois, 61554, United States
Penn State Health Saint Joseph Medical Center

Reading, Pennsylvania, 19605, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Perry Memorial Hospital

Princeton, Illinois, 61356, United States
Pomona Valley Hospital Medical Center

Pomona, California, 91767, United States
Porter Adventist Hospital

Denver, Colorado, 80210, United States
Portneuf Medical Center

Pocatello, Idaho, 83201, United States
Portsmouth Regional Hospital

Portsmouth, New Hampshire, 03802, United States
Porubcin, Michael MD (UIA Investigator)

Moline, Illinois, 61265, United States
Pottstown Memorial Medical Center

Pottstown, Pennsylvania, 19464, United States
Presbyterian - Saint Lukes Medical Center - Health One

Denver, Colorado, 80218, United States
Proctor Hospital

Peoria, Illinois, 61614, United States
Providence Milwaukie Hospital

Milwaukie, Oregon, 97222, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Reid Hospital and Health Care Services

Richmond, Indiana, 47374, United States
Ridgeview Medical Center

Waconia, Minnesota, 55387, United States
Riverside Methodist Hospital

Columbus, Ohio, 43214, United States
Rose Medical Center

Denver, Colorado, 80220, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Rush - Copley Medical Center

Aurora, Illinois, 60504, United States
SCL Health Lutheran Medical Center

Wheat Ridge, Colorado, 80033, United States
Sacred Heart Hospital

Eau Claire, Wisconsin, 54701, United States
Saint Alexius Medical Center

Bismarck, North Dakota, 58501, United States
Saint Ann's Hospital

Westerville, Ohio, 43081, United States
Saint Anthony Hospital

Lakewood, Colorado, 80228, United States
Saint Charles Hospital

Oregon, Ohio, 43616, United States
Saint Francis Hospital and Medical Center - Topeka

Topeka, Kansas, 66606, United States
Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States
Saint James Community Hospital and Cancer Treatment Center

Butte, Montana, 59701, United States
Saint John Hospital and Medical Center

Detroit, Michigan, 48236, United States
Saint John Macomb-Oakland Hospital

Warren, Michigan, 48093, United States
Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States
Saint Joseph Medical Center

Bloomington, Illinois, 61701, United States
Saint Joseph Mercy Hospital

Ann Arbor, Michigan, 48106-0995, United States
Saint Joseph Mercy Oakland

Pontiac, Michigan, 48341, United States
Saint Joseph Mercy Port Huron

Port Huron, Michigan, 48060, United States
Saint Joseph Regional Medical Center-Mishawaka

Mishawaka, Indiana, 46545, United States
Saint Joseph's Hospital

Marshfield, Wisconsin, 54449, United States
Saint Joseph's Hospital - Healtheast

Saint Paul, Minnesota, 55102, United States
Saint Luke's Hospital

Maumee, Ohio, 43537, United States
Saint Luke's Regional Medical Center

Sioux City, Iowa, 51104, United States
Saint Margaret's Hospital

Spring Valley, Illinois, 61362, United States
Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States
Saint Mary Mercy Hospital

Livonia, Michigan, 48154, United States
Saint Mary's Hospital

Green Bay, Wisconsin, 54303, United States
Saint Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, 81502, United States
Saint Mary's of Michigan

Saginaw, Michigan, 48601, United States
Saint Michael's Hospital

Stevens Point, Wisconsin, 54481, United States
Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States
Saint Peter's Community Hospital

Helena, Montana, 59601, United States
Saint Rose Hospital

Hayward, California, 94545, United States
Saint Vincent Healthcare

Billings, Montana, 59101, United States
Saint Vincent Hospital

Green Bay, Wisconsin, 54301, United States
Saint Vincent Hospital and Health Care Center

Indianapolis, Indiana, 46260, United States
Saint Vincent Mercy Medical Center

Toledo, Ohio, 43608, United States
Samaritan North Health Center

Dayton, Ohio, 45415, United States
Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501, United States
Scott and White Memorial Hospital

Temple, Texas, 76508, United States
Sharis, Christine M MD (UIA Investigator)

Moline, Illinois, 61265, United States
Sidney and Lois Eskenazi Hospital

Indianapolis, Indiana, 46202, United States
Siouxland Regional Cancer Center

Sioux City, Iowa, 51101, United States
Sky Ridge Medical Center

Lone Tree, Colorado, 80124, United States
South Bend Clinic

South Bend, Indiana, 46617, United States
Southeast Missouri Hospital

Cape Girardeau, Missouri, 63701, United States
Sparrow Hospital

Lansing, Michigan, 48912, United States
Spector, David MD (UIA Investigator)

Moline, Illinois, 61265, United States
Springfield Regional Medical Center

Springfield, Ohio, 45505, United States
State University of New York Upstate Medical University

Syracuse, New York, 13210, United States
Stoffel, Thomas J MD (UIA Investigator)

Moline, Illinois, 61265, United States
Stormont-Vail Regional Health Center

Topeka, Kansas, 66604, United States
Swedish Medical Center

Englewood, Colorado, 80113, United States
Swedish Medical Center-First Hill

Seattle, Washington, 98122-4307, United States
The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817, United States
The Medical Center of Aurora

Aurora, Colorado, 80012, United States
The Memorial Hospital at Easton

Easton, Maryland, 21601, United States
The Polyclinic

Seattle, Washington, 98122, United States
The Toledo Hospital/Toledo Children's Hospital

Toledo, Ohio, 43606, United States
Toledo Clinic Cancer Centers-Bowling Green

Bowling Green, Ohio, 43402, United States
Toledo Clinic Cancer Centers-Maumee

Maumee, Ohio, 43537, United States
Toledo Clinic Cancer Centers-Monroe

Monroe, Michigan, 48162, United States
Toledo Clinic Cancer Centers-Oregon

Oregon, Ohio, 43616, United States
Toledo Clinic Cancer Centers-Toledo

Toledo, Ohio, 43623, United States
Toledo Community Hospital Oncology Program CCOP

Toledo, Ohio, 43617, United States
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center

Maumee, Ohio, 43537, United States
Tom K Lee Inc

Oakland, California, 94609, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
UW Cancer Center Johnson Creek

Johnson Creek, Wisconsin, 53038, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Hawaii Cancer Center

Honolulu, Hawaii, 96813, United States
University of Illinois

Chicago, Illinois, 60612, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Rochester

Rochester, New York, 14642, United States
University of Tennessee Health Science Center

Memphis, Tennessee, 38163, United States
University of Toledo

Toledo, Ohio, 43614, United States
University of Washington Medical Center

Seattle, Washington, 98195, United States
University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792, United States
Upper Valley Medical Center

Troy, Ohio, 45373, United States
Valley Care Health System - Pleasanton

Pleasanton, California, 94588, United States
Valley Medical Oncology Consultants

Pleasanton, California, 94588, United States
Valley Medical Oncology Consultants-Castro Valley

Castro Valley, California, 94546, United States
Valley Medical Oncology Consultants-Fremont

Fremont, California, 94538, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Veteran Affairs Medical Center

Dayton, Ohio, 45428, United States
Via Christi Regional Medical Center

Wichita, Kansas, 67214, United States
Virginia Piper Cancer Institute

Minneapolis, Minnesota, 55407, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wayne Hospital

Greenville, Ohio, 45331, United States
Wayne Memorial Hospital

Goldsboro, North Carolina, 27534, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Welch Cancer Center

Sheridan, Wyoming, 82801, United States
West Virginia University Charleston

Charleston, West Virginia, 25304, United States
West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States
Western Oncology Research Consortium

Portland, Oregon, 97213, United States
Wichita NCI Community Oncology Research Program

Wichita, Kansas, 67214, United States
Woodwinds Health Campus

Woodbury, Minnesota, 55125, United States
York Hospital

York Village, Maine, 03909, United States
Zale Lipshy University Hospital

Dallas, Texas, 75235, United States

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